| Gene Symbol |
NEURL1
|
| Entrez Gene |
9148
|
| Alt Symbol |
NEUR1, NEURL, RNF67, bA416N2.1, neu, neu-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuralized E3 ubiquitin protein ligase 1
|
| Other Description |
E3 ubiquitin-protein ligase NEURL1|RING finger protein 67|h-neuralized 1|neuralized homolog|neuralized-like protein 1A
|
| Swissprots |
Q5TDR3 Q9H463 O76050 Q5TDR2 Q8TAN0
|
| Accessions |
CCQ43253 EAW49628 EAW49629 EAW49630 O76050 AF029729 AAD01887 AK299620 BAG61548 BC026336 AAH26336 U87864 AAC17474 XM_005270269 XP_005270326 XM_005270270 XP_005270327 XM_011540331 XP_011538633 XM_011540332 XP_011538634 XM_011540333 XP_011538635 XM_011540334 XP_011538636 XM_011540335 XP_011538637 XR_945866 NM_004210 NP_004201
|
| Function |
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. {ECO:0000269|PubMed:20847082}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:20847082}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues. {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:9519875}.
|