NEURL1

Gene Symbol	NEURL1
Entrez Gene	9148
Alt Symbol	NEUR1, NEURL, RNF67, bA416N2.1, neu, neu-1
Species	Human
Gene Type	protein-coding
Description	neuralized E3 ubiquitin protein ligase 1
Other Description	E3 ubiquitin-protein ligase NEURL1|RING finger protein 67|h-neuralized 1|neuralized homolog|neuralized-like protein 1A
Swissprots	Q5TDR3 Q9H463 O76050 Q5TDR2 Q8TAN0
Accessions	CCQ43253 EAW49628 EAW49629 EAW49630 O76050 AF029729 AAD01887 AK299620 BAG61548 BC026336 AAH26336 U87864 AAC17474 XM_005270269 XP_005270326 XM_005270270 XP_005270327 XM_011540331 XP_011538633 XM_011540332 XP_011538634 XM_011540333 XP_011538635 XM_011540334 XP_011538636 XM_011540335 XP_011538637 XR_945866 NM_004210 NP_004201
Function	Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. {ECO:0000269|PubMed:20847082}.
Subcellular Location	Cytoplasm, perinuclear region {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:20847082}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. {ECO:0000250}.
Tissue Specificity	Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues. {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:9519875}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NEURL1 / NEURL Antibody Blocking Peptide - LS-E15837 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEURL1 / NEURL Antibody Blocking Peptide - LS-E9752 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEURL-Antibody-Center-Blocking-Peptide - BP8737c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NEURL peptide - orb218223 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

NEU1 protein (His tag) - 80R-2429 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

NEURL Blocking Peptide - 33R-8032 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NEURL1 Blocking Peptide - abx063554 from Abbexa Category Peptide Species Human

NEURL fusion protein - ag13531 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

NEURL1 Blocking Peptide - CBP2360 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Neuralized-1 (V250) Peptide - BS3342P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Neuralized-like protein 1A(NEURL) - CSB-YP015721HU CSB-EP015721HU CSB-BP015721HU CSB-MP015721HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NEURL Recombinant Protein Antigen - NBP1-92177PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NEURL Peptide, Human - M34GP10310H from Creative Peptides Category Peptide Source Synthetic. Species Human

NEURL Antibody - SH-A13981 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

Neuralized-like protein 1A (NEURL), Recombinant Protein - MBS1078666 from MyBioSource Category Protein Prices $1,370.00, $1,370.00, $1,590.00, $1,590.00, $2,280.00, $2,280.00, $2,745.00, $2,745.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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