NEURL1

Gene Symbol NEURL1
Entrez Gene 9148
Alt Symbol NEUR1, NEURL, RNF67, bA416N2.1, neu, neu-1
Species Human
Gene Type protein-coding
Description neuralized E3 ubiquitin protein ligase 1
Other Description E3 ubiquitin-protein ligase NEURL1|RING finger protein 67|h-neuralized 1|neuralized homolog|neuralized-like protein 1A
Swissprots Q5TDR3 Q9H463 O76050 Q5TDR2 Q8TAN0
Accessions CCQ43253 EAW49628 EAW49629 EAW49630 O76050 AF029729 AAD01887 AK299620 BAG61548 BC026336 AAH26336 U87864 AAC17474 XM_005270269 XP_005270326 XM_005270270 XP_005270327 XM_011540331 XP_011538633 XM_011540332 XP_011538634 XM_011540333 XP_011538635 XM_011540334 XP_011538636 XM_011540335 XP_011538637 XR_945866 NM_004210 NP_004201
Function Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. {ECO:0000269|PubMed:20847082}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:20847082}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. {ECO:0000250}.
Tissue Specificity Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues. {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:9519875}.

NEURL CRISPR/Cas9 KO Plasmid (h) - sc-409208 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEURL HDR Plasmid (h) - sc-409208-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEURL Double Nickase Plasmid (h) - sc-409208-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEURL Double Nickase Plasmid (h2) - sc-409208-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEURL CRISPR Activation Plasmid (h) - sc-409208-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEURL CRISPR Activation Plasmid (h2) - sc-409208-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEURL Lentiviral Activation Particles (h) - sc-409208-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEURL Lentiviral Activation Particles (h2) - sc-409208-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEURL siRNA (h) - sc-90727 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NEURL shRNA Plasmid (h) - sc-90727-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NEURL shRNA (h) Lentiviral Particles - sc-90727-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NEURL RNAi - H00009148-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU039781 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15219 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15219 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NEURL1 siRNA (Human) - CRH6054 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NEURL (NM_004210.4) - SHH351493 from Creative biogene

Category siRNA
Species Reactivities Human

Human NEURL1 siRNA - orb266556 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NEURL1 shRNA Plasmid (Human) - CHH6054 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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