SPIRE1

Gene Symbol SPIRE1
Entrez Gene 56907
Alt Symbol Spir-1
Species Human
Gene Type protein-coding
Description spire-type actin nucleation factor 1
Other Description protein spire homolog 1|spire actin nucleation factor 1|spire family actin nucleation factor 1|spire homolog 1
Swissprots A8K2B5 Q9ULT4 J3KQR5 Q9NQ71 Q1RMD4 J3KQ50 Q8NDP1 Q08AE8
Accessions EAX01544 EAX01545 EAX01546 Q08AE8 AB032961 BAA86449 AJ277587 CAB96370 AK025433 AK090999 AK290180 BAF82869 AK301711 BAG63182 AL833817 CAD38680 BC016825 AAH16825 BC115005 AAI15006 BC125206 AAI25207 BC125207 AAI25208 DB056921 DB506330 DR001109 XM_005258122 XP_005258179 XM_011525700 XP_011524002 XM_011525701 XP_011524003 XM_011525702 XP_011524004 XM_011525703 XP_011524005 NM_001128626 NP_001122098 NM_001128627 NP_001122099 NM_020148 NP_064533
Function Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11747823}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11747823}. Cell membrane {ECO:0000269|PubMed:11747823}; Peripheral membrane protein {ECO:0000269|PubMed:11747823}; Cytoplasmic side {ECO:0000269|PubMed:11747823}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11. {ECO:0000250}.
Top Pathways Dorso-ventral axis formation

Spir-1 (F-15) - sc-85161 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

Spir-1 (K-19) - sc-85162 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Spir-1 (K-19): sc-85162. Western blot analysis of Spir-1 expression in Hep G2 (A), Jurkat (B), U-251-MG (C), ARPE-19 (D), RPE-J (E) and SK-OV-3 (F) whole cell lysates.

Spir-1 (P-17) - sc-85163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Spir-1 (P-17): sc-85163. Western blot analysis of Spir-1 expression in U-251-MG (A), HEK293 (B), ARPE-19 (C) and RPE-J (D) whole cell lysates.

Anti-SPIRE1 antibody - ab130403 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SPIRE1 antibody (ab130403) at 1/250 dilutionLane 1 : RT4 cell lysateLane 2 : U-251 MG cell lysateLane 3 : Human Plasma lysateLane 4 : Human Liver lysateLane 5 : Human Tonsil lysate

Anti-SPIRE1 antibody - ab57463 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57463 SPIRE1 antibody at 1ug/ml.

Anti-SPIRE1 antibody - ab130463 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab130463, at 1/50 dilution, staining SPIRE1 in paraffin-embedded Human liver tissue by Immunohistochemistry

Anti-SPIRE1 antibody - C-terminal - ab173104 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SPIRE1 antibody - C-terminal (ab173104) at 1/100 dilution + 293 cell lysate at 35 µg

Anti-SPIRE1 Antibody (aa488-505) - LS-C144198 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SPIRE1 Antibody (aa488-505) - LS-C148951 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SPIRE1 Antibody (aa665-691, APC) - LS-C241179 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPIRE1 Antibody (aa665-691, AP) - LS-C241180 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPIRE1 Antibody (aa665-691, Biotin) - LS-C241181 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPIRE1 Antibody (aa665-691, FITC) - LS-C241182 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPIRE1 Antibody (aa665-691, PE) - LS-C241184 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPIRE1 Antibody (aa665-691, Azide-free, HRP) - LS-C248236 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPIRE1 Antibody (aa664-691) - LS-C325334 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SPIRE1 Antibody (aa665-691) - LS-C157076 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SPIRE1 Antibody western blot of 293 cell line lysates (35 ug/lane). The SPIRE1 antibody detected the SPIRE1 protein (arrow).

SPIRE1 Antibody - NBP1-92438 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SPIRE1 Antibody [NBP1-92438] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

SPIRE1 Antibody - NBP1-92439 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SPIRE1 Antibody [NBP1-92439] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10. Lane 2: SK-MEL-30

SPIRE1 Antibody (4C5) - H00056907-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C5
Western Blot: SPIRE1 Antibody (4C5) [H00056907-M01] - Analysis of SPIRE1 expression in transfected 293T cell line by SPIRE1 monoclonal antibody (M01), clone 4C5.Lane 1: SPIRE1 transfected lysate(15 KDa).Lane 2: Non-transfected lysate.

SPIRE1 Antibody - H00056907-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

ANTI-SPIRE1 (C-TERM) antibody produced in rabbit - SAB1304514 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SPIRE1 (C-term): <B>Cat. No. SAB1304514</B>: SPIRE1 Antibody (C-term) western blot analysis in HEK_293 cell line lysates (35 μg/lane).

Anti-Spire1 antibody produced in rabbit - HPA040737 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SPIRE1: <B>Cat. No. HPA040737</B>: Immunohistochemical staining of human lateral ventricle shows strong nuclear positivity in neuronal cells.

Anti-Spire1 antibody produced in rabbit - HPA040942 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SPIRE1: <B>Cat. No. HPA040942</B>: Immunohistochemical staining of human liver shows strong cytoplasmic and membranous positivity in hepatocytes.

SPIRE1-Antibody-C-term - AP17465b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
SPIRE1 Antibody (C-term) (Cat. #AP17465b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SPIRE1 antibody detected the SPIRE1 protein (arrow).
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