SPIRE1

Gene Symbol	SPIRE1
Entrez Gene	56907
Alt Symbol	Spir-1
Species	Human
Gene Type	protein-coding
Description	spire-type actin nucleation factor 1
Other Description	protein spire homolog 1|spire actin nucleation factor 1|spire family actin nucleation factor 1|spire homolog 1
Swissprots	A8K2B5 Q9ULT4 J3KQR5 Q9NQ71 Q1RMD4 J3KQ50 Q8NDP1 Q08AE8
Accessions	EAX01544 EAX01545 EAX01546 Q08AE8 AB032961 BAA86449 AJ277587 CAB96370 AK025433 AK090999 AK290180 BAF82869 AK301711 BAG63182 AL833817 CAD38680 BC016825 AAH16825 BC115005 AAI15006 BC125206 AAI25207 BC125207 AAI25208 DB056921 DB506330 DR001109 XM_005258122 XP_005258179 XM_011525700 XP_011524002 XM_011525701 XP_011524003 XM_011525702 XP_011524004 XM_011525703 XP_011524005 NM_001128626 NP_001122098 NM_001128627 NP_001122099 NM_020148 NP_064533
Function	Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11747823}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11747823}. Cell membrane {ECO:0000269|PubMed:11747823}; Peripheral membrane protein {ECO:0000269|PubMed:11747823}; Cytoplasmic side {ECO:0000269|PubMed:11747823}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11. {ECO:0000250}.
Top Pathways	Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SPIRE1 full length protein - ab163422 from Abcam Category Protein Source Wheat germ Species Human

Human SPIRE1 protein fragment - ab163423 from Abcam Category Protein Source Wheat germ Species Human

SPIRE1 Antibody Blocking Peptide - LS-E5052 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SPIRE1 Protein - H00056907-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human SPIRE1 Protein - H00056907-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SPIRE1-Antibody-C-term-Blocking-Peptide - BP17465b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPIRE1 - H00056907-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

SPIRE1 - H00056907-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SPIRE1 - H00056907-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SPIRE1 fusion protein - ag1798 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SPIRE1 fusion protein - ag14445 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SPIRE1 (transcript variant 2) - TP313848 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SPIRE1 Protein - NBP1-92439PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SPIRE1 Recombinant Protein Antigen - NBP1-92438PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SPIRE1 Peptide, Human - M34GP15067H from Creative Peptides Category Peptide Source Synthetic. Species Human

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