| Gene Symbol |
SPIRE1
|
| Entrez Gene |
56907
|
| Alt Symbol |
Spir-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spire-type actin nucleation factor 1
|
| Other Description |
protein spire homolog 1|spire actin nucleation factor 1|spire family actin nucleation factor 1|spire homolog 1
|
| Swissprots |
A8K2B5 Q9ULT4 J3KQR5 Q9NQ71 Q1RMD4 J3KQ50 Q8NDP1 Q08AE8
|
| Accessions |
EAX01544 EAX01545 EAX01546 Q08AE8 AB032961 BAA86449 AJ277587 CAB96370 AK025433 AK090999 AK290180 BAF82869 AK301711 BAG63182 AL833817 CAD38680 BC016825 AAH16825 BC115005 AAI15006 BC125206 AAI25207 BC125207 AAI25208 DB056921 DB506330 DR001109 XM_005258122 XP_005258179 XM_011525700 XP_011524002 XM_011525701 XP_011524003 XM_011525702 XP_011524004 XM_011525703 XP_011524005 NM_001128626 NP_001122098 NM_001128627 NP_001122099 NM_020148 NP_064533
|
| Function |
Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11747823}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11747823}. Cell membrane {ECO:0000269|PubMed:11747823}; Peripheral membrane protein {ECO:0000269|PubMed:11747823}; Cytoplasmic side {ECO:0000269|PubMed:11747823}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11. {ECO:0000250}.
|
| Top Pathways |
Dorso-ventral axis formation
|
![Western Blot: SPIRE1 Overexpression Lysate (Adult Normal) [NBP2-06666] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SPIRE1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6171_SPIRE1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06666-img0001.jpg)