| Gene Symbol |
DCXR
|
| Entrez Gene |
51181
|
| Alt Symbol |
DCR, HCR2, HCRII, KIDCR, P34H, PNTSU, SDR20C1, XR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dicarbonyl/L-xylulose reductase
|
| Other Description |
L-xylulose reductase|carbonyl reductase 2|carbonyl reductase II|kidney dicarbonyl reductase|short chain dehydrogenase/reductase family 20C member 1|short chain dehydrogenase/reductase family 20C, member 1|sperm surface protein P34H
|
| Swissprots |
Q9BTZ3 Q9UHY9 Q7Z4W1
|
| Accessions |
EAW89732 EAW89733 Q7Z4W1 AA446582 AB013846 BAB64299 AF113123 AAF14864 AF139841 AAP97273 AF515623 AAN59786 AF515624 AAO15991 AF515625 AAM54026 AK226040 AV653537 BC001470 AAH01470 BC003018 AAH03018 BG434209 BT006881 AAP35527 CB959852 NM_001195218 NP_001182147 NM_016286 NP_057370
|
| Function |
Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
|
| Subcellular Location |
Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Probably recruited to membranes via an interaction with phosphatidylinositol. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis. {ECO:0000269|PubMed:10385429, ECO:0000269|PubMed:11882650}.
|
| Top Pathways |
Pentose and glucuronate interconversions
|
![Western Blot: DCXR Overexpression Lysate (Adult Normal) [NBL1-09762] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DCXR.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2675_DCXR%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09762-img0002.jpg)