DCXR

Gene Symbol DCXR
Entrez Gene 51181
Alt Symbol DCR, HCR2, HCRII, KIDCR, P34H, PNTSU, SDR20C1, XR
Species Human
Gene Type protein-coding
Description dicarbonyl/L-xylulose reductase
Other Description L-xylulose reductase|carbonyl reductase 2|carbonyl reductase II|kidney dicarbonyl reductase|short chain dehydrogenase/reductase family 20C member 1|short chain dehydrogenase/reductase family 20C, member 1|sperm surface protein P34H
Swissprots Q9BTZ3 Q9UHY9 Q7Z4W1
Accessions EAW89732 EAW89733 Q7Z4W1 AA446582 AB013846 BAB64299 AF113123 AAF14864 AF139841 AAP97273 AF515623 AAN59786 AF515624 AAO15991 AF515625 AAM54026 AK226040 AV653537 BC001470 AAH01470 BC003018 AAH03018 BG434209 BT006881 AAP35527 CB959852 NM_001195218 NP_001182147 NM_016286 NP_057370
Function Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Subcellular Location Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Probably recruited to membranes via an interaction with phosphatidylinositol. {ECO:0000250}.
Tissue Specificity Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis. {ECO:0000269|PubMed:10385429, ECO:0000269|PubMed:11882650}.
Top Pathways Pentose and glucuronate interconversions

L-xylulose reductase CRISPR/Cas9 KO Plasmid (h) - sc-412140 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

L-xylulose reductase HDR Plasmid (h) - sc-412140-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

L-xylulose reductase Double Nickase Plasmid (h) - sc-412140-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

L-xylulose reductase Double Nickase Plasmid (h2) - sc-412140-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

L-xylulose reductase CRISPR Activation Plasmid (h) - sc-412140-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

L-xylulose reductase CRISPR Activation Plasmid (h2) - sc-412140-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

L-xylulose reductase Lentiviral Activation Particles (h) - sc-412140-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

L-xylulose reductase Lentiviral Activation Particles (h2) - sc-412140-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

L-xylulose reductase siRNA (h) - sc-62536 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

L-xylulose reductase shRNA Plasmid (h) - sc-62536-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

L-xylulose reductase shRNA (h) Lentiviral Particles - sc-62536-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU021591 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7016 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7016 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DCXR siRNA (Human) - CRH9587 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DCXR RNAi - H00051181-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

DCXR - MBS8207962 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DCXR (NM_016286.3) - SHH275513 from Creative biogene

Category siRNA
Species Reactivities Human

Human DCXR siRNA - orb270089 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DCXR shRNA Plasmid (Human) - CHH9587 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DCXR miRNA 3'UTR clone - MiUTR3H-09932 from Creative biogene

Species Reactivities Human
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