DCXR

Gene Symbol DCXR
Entrez Gene 51181
Alt Symbol DCR, HCR2, HCRII, KIDCR, P34H, PNTSU, SDR20C1, XR
Species Human
Gene Type protein-coding
Description dicarbonyl/L-xylulose reductase
Other Description L-xylulose reductase|carbonyl reductase 2|carbonyl reductase II|kidney dicarbonyl reductase|short chain dehydrogenase/reductase family 20C member 1|short chain dehydrogenase/reductase family 20C, member 1|sperm surface protein P34H
Swissprots Q9BTZ3 Q9UHY9 Q7Z4W1
Accessions EAW89732 EAW89733 Q7Z4W1 AA446582 AB013846 BAB64299 AF113123 AAF14864 AF139841 AAP97273 AF515623 AAN59786 AF515624 AAO15991 AF515625 AAM54026 AK226040 AV653537 BC001470 AAH01470 BC003018 AAH03018 BG434209 BT006881 AAP35527 CB959852 NM_001195218 NP_001182147 NM_016286 NP_057370
Function Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
Subcellular Location Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Probably recruited to membranes via an interaction with phosphatidylinositol. {ECO:0000250}.
Tissue Specificity Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis. {ECO:0000269|PubMed:10385429, ECO:0000269|PubMed:11882650}.
Top Pathways Pentose and glucuronate interconversions

L-xylulose reductase (H-84) - sc-292501 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
L-xylulose reductase (H-84): sc-292501. Western blot analysis of L-xylulose reductase expression in HeLa (A), A-431 (B) and Hep G2 (C) whole cell lysates.

L-xylulose reductase (P-18) - sc-54683 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

L-xylulose reductase (S-14) - sc-54834 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

L-xylulose reductase (18-Q) - sc-100552 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
L-xylulose reductase (18-Q): sc-100552. Western blot analysis of L-xylulose reductase expression in A-431 whole cell lysate.

Anti-DCXR antibody - ab11800 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Ab11800 staining (0.1µg/ml) of Human Kidney lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Anti-DCXR antibody - ab82303 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DCXR antibody (ab82303) at 1/50 dilution + Mouse lung tissue lysate at 35 µg

Anti-DCXR antibody - ab191369 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling DCXR with ab191369 at 7.5 µg/ml.

Anti-DCXR antibody - ab96778 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-DCXR antibody (ab96778) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-DCXR antibody - ab57315 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DCXR antibody [4G4AF5] - ab110283 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4G4AF5
Anti-DCXR antibody [4G4AF5] (ab110283) at 1 µg/ml + Human liver mitochondria at 20 µgSecondaryGoat anti-mouse conjugated to AP

Anti-DCXR antibody [9C9] - ab118064 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9C9
All lanes : Anti-DCXR antibody [9C9] (ab118064) at 1/2000 dilutionLane 1 : HEK293T cell lysate, transfected with pCMV6-ENTRY control Lane 2 : HEK293T cell lysate, transfected with pCMV6-ENTRY DCXR cDNALysates/proteins at 5 µg per lane.

Anti-DCXR Antibody (aa151-200) - LS-C40385 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DCXR antibody LS-C40385 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-DCXR Antibody - LS-C307196 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-DCXR Antibody (aa79-106) - LS-C100645 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human kidney carcinoma with DCXR Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-DCXR Antibody - LS-C310098 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DCXR Antibody (clone 6A6) - LS-C133753 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6A6
Immunoperoxidase of monoclonal antibody to DCXR on formalin-fixed paraffin-embedded human prostate. [antibody concentration 1 ug/ml]

Anti-DCXR Antibody - LS-C310099 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DCXR Antibody (aa145-245, Azide-free) - LS-C327171 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-DCXR Antibody (clone 9C9) - LS-C114903 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9C9
IHC of paraffin-embedded Carcinoma of liver tissue using anti-DCXR mouse monoclonal antibody. (Dilution 1:50).

Anti-DCXR Antibody (clone 4D11) - LS-C114894 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4D11
IHC of paraffin-embedded Carcinoma of liver tissue using anti-DCXR mouse monoclonal antibody. (Dilution 1:50).

Anti-DCXR Antibody (clone 4H10) - LS-C114893 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4H10
IHC of paraffin-embedded prostate tissue using anti-DCXR mouse monoclonal antibody. (Dilution 1:50).

Anti-DCXR Antibody (aa182-244) IHC-plus™ - LS-B10774 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-DCXR antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10774 concentration 7.5 ug/ml.

Anti-DCXR Antibody (aa232-244) IHC-plus™ - LS-B9182 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-DCXR antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-DCXR Antibody (clone 7D11) - LS-C114851 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7D11
IHC of paraffin-embedded thyroid tissue using anti-DCXR mouse monoclonal antibody. (Dilution 1:50).

DCXR Antibody (7D11) - NBP2-02192 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7D11
Western Blot: DCXR Antibody (7D11) [NBP2-02192] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DCXR (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-DCXR.
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