| Gene Symbol |
SUPT4H1
|
| Entrez Gene |
6827
|
| Alt Symbol |
SPT4, SPT4H, SUPT4H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of Ty 4 homolog 1 (S. cerevisiae)
|
| Other Description |
DRB sensitivity-inducing factor 14 kDa subunit|DSIF p14|small hSpt4 subunit|transcription elongation factor SPT4
|
| Swissprots |
Q6ZP89 B2R4X8 P63272 Q16550 Q62387 D3DTZ4
|
| Accessions |
EAW94464 EAW94465 EAW94466 EAW94467 P63272 AA311965 AI342302 AI735030 AK129758 BAC85230 AK311986 BAG34925 BC002802 AAH02802 BG026473 BP196741 BP318625 BX331655 CR407663 CAG28591 EU446710 ABZ92239 FN160415 U38817 AAB18675 U38818 AAB18674 U43923 AAB07814 NM_003168 NP_003159 NR_073470
|
| Function |
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptio
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:8649394}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:8649394, ECO:0000269|PubMed:8786137}.
|