SUPT4H1

Gene Symbol SUPT4H1
Entrez Gene 6827
Alt Symbol SPT4, SPT4H, SUPT4H
Species Human
Gene Type protein-coding
Description suppressor of Ty 4 homolog 1 (S. cerevisiae)
Other Description DRB sensitivity-inducing factor 14 kDa subunit|DSIF p14|small hSpt4 subunit|transcription elongation factor SPT4
Swissprots Q6ZP89 B2R4X8 P63272 Q16550 Q62387 D3DTZ4
Accessions EAW94464 EAW94465 EAW94466 EAW94467 P63272 AA311965 AI342302 AI735030 AK129758 BAC85230 AK311986 BAG34925 BC002802 AAH02802 BG026473 BP196741 BP318625 BX331655 CR407663 CAG28591 EU446710 ABZ92239 FN160415 U38817 AAB18675 U38818 AAB18674 U43923 AAB07814 NM_003168 NP_003159 NR_073470
Function Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptio
Subcellular Location Nucleus {ECO:0000269|PubMed:8649394}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:8649394, ECO:0000269|PubMed:8786137}.

SPT4 CRISPR/Cas9 KO Plasmid (h) - sc-404448 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT4 HDR Plasmid (h) - sc-404448-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT4 Double Nickase Plasmid (h) - sc-404448-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT4 Double Nickase Plasmid (h2) - sc-404448-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT4 CRISPR Activation Plasmid (h) - sc-404448-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT4 CRISPR Activation Plasmid (h2) - sc-404448-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT4 Lentiviral Activation Particles (h) - sc-404448-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT4 Lentiviral Activation Particles (h2) - sc-404448-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPT4 siRNA (h) - sc-38438 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPT4 shRNA Plasmid (h) - sc-38438-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPT4 shRNA (h) Lentiviral Particles - sc-38438-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Suppressor of Ty 4 homolog 1 RNAi - H00006827-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU220731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $140.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20843 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20843 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SUPT4H1 siRNA (Human) - CRH4667 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SUPT4H1 - MBS8221424 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human SUPT4H1 siRNA - orb265169 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SUPT4H1 shRNA Plasmid (Human) - CHH4667 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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