SUPT4H1

Gene Symbol	SUPT4H1
Entrez Gene	6827
Alt Symbol	SPT4, SPT4H, SUPT4H
Species	Human
Gene Type	protein-coding
Description	suppressor of Ty 4 homolog 1 (S. cerevisiae)
Other Description	DRB sensitivity-inducing factor 14 kDa subunit|DSIF p14|small hSpt4 subunit|transcription elongation factor SPT4
Swissprots	Q6ZP89 B2R4X8 P63272 Q16550 Q62387 D3DTZ4
Accessions	EAW94464 EAW94465 EAW94466 EAW94467 P63272 AA311965 AI342302 AI735030 AK129758 BAC85230 AK311986 BAG34925 BC002802 AAH02802 BG026473 BP196741 BP318625 BX331655 CR407663 CAG28591 EU446710 ABZ92239 FN160415 U38817 AAB18675 U38818 AAB18674 U43923 AAB07814 NM_003168 NP_003159 NR_073470
Function	Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptio
Subcellular Location	Nucleus {ECO:0000269|PubMed:8649394}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:8649394, ECO:0000269|PubMed:8786137}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SPT4 (S-15) - sc-13835 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SPT4 (FL-117) - sc-28677 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SPT4 (N-14) - sc-13834 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SPT4 (3079C1a) - sc-81384 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-Suppressor of Ty 4 homolog 1 antibody - ab105426 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Suppressor of Ty 4 homolog 1 antibody - ab157563 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Suppressor of Ty 4 homolog 1 antibody [3079C1a] - ab54350 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3079C1a

Anti-Suppressor of Ty 4 homolog 1 antibody [EPR6100(2)] - ab129187 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6100(2)

Anti-SUPT4H1 / SPT4 Antibody - LS-C76159 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-SUPT4H1 / SPT4 Antibody (clone 3079C1a) - LS-C184480 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 3079C1a

Anti-SUPT4H1 / SPT4 Antibody (Internal, clone EPR6100(2)) - LS-C152504 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6100(2)

Anti-SUPT4H1 / SPT4 Antibody (clone 5F12) - LS-C338742 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5F12

Anti-SUPT4H1 / SPT4 Antibody (clone 6B10) - LS-C340630 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 6B10

Anti-SUPT4H1 / SPT4 Antibody (aa35-84) - LS-C116164 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SUPT4H1 / SPT4 Antibody (clone 3079C1a) - LS-C342517 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3079C1a

Anti-SUPT4H1 / SPT4 Antibody (aa57-106) - LS-C170126 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SUPT4H1 / SPT4 Antibody (clone 3G4) - LS-C198288 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3G4

Suppressor of Ty 4 homolog 1 Antibody - NBP2-31794 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Suppressor of Ty 4 homolog 1 Antibody - H00006827-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Suppressor of Ty 4 homolog 1 Antibody (3G4) - H00006827-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3G4

Monoclonal Anti-SUPT4H1, (C-terminal) antibody produced in mouse - SAB1402933 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3G4

Anti-SUPT4H1 antibody produced in rabbit - HPA059748 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SUPT4H1 (71-85) antibody produced in rabbit - SAB1100988 from Sigma-Aldrich Prices $328.50 Sizes 200 µl Host Rabbit Clonality Polyclonal

SUPT4H1 antibody - middle region (ARP38258_P050) - ARP38258_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SUPT4H1 antibody - 10R-1444 from Fitzgerald Prices $190.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 3079C1a

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