SUPT4H1

Gene Symbol	SUPT4H1
Entrez Gene	6827
Alt Symbol	SPT4, SPT4H, SUPT4H
Species	Human
Gene Type	protein-coding
Description	suppressor of Ty 4 homolog 1 (S. cerevisiae)
Other Description	DRB sensitivity-inducing factor 14 kDa subunit|DSIF p14|small hSpt4 subunit|transcription elongation factor SPT4
Swissprots	Q6ZP89 B2R4X8 P63272 Q16550 Q62387 D3DTZ4
Accessions	EAW94464 EAW94465 EAW94466 EAW94467 P63272 AA311965 AI342302 AI735030 AK129758 BAC85230 AK311986 BAG34925 BC002802 AAH02802 BG026473 BP196741 BP318625 BX331655 CR407663 CAG28591 EU446710 ABZ92239 FN160415 U38817 AAB18675 U38818 AAB18674 U43923 AAB07814 NM_003168 NP_003159 NR_073470
Function	Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptio
Subcellular Location	Nucleus {ECO:0000269|PubMed:8649394}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:8649394, ECO:0000269|PubMed:8786137}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Suppressor of Ty 4 homolog 1 full length protein - ab116940 from Abcam Category Protein Source Wheat germ Species Human

Human Suppressor of Ty 4 homolog 1 full length protein - ab116941 from Abcam Category Protein Source Wheat germ Species Human

Human Suppressor of Ty 4 homolog 1 protein fragment - ab159613 from Abcam Category Protein Source Wheat germ Species Human

SUPT4H1 / SPT4 Antibody Blocking Peptide - LS-E13742 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Suppressor of Ty 4 homolog 1 Protein - H00006827-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Suppressor of Ty 4 homolog 1 Recombinant Protein - H00006827-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Suppressor of Ty 4 homolog 1 Protein - H00006827-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SUPT4H1 - H00006827-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SUPT4H1 - H00006827-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SUPT4H1 - H00006827-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

SUPT4H1 - H00006827-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SUPT4H1 - H00006827-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SUPT4H1 - H00006827-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SUPT4H1 - H00006827-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SUPT4H1 fusion protein - Ag7678 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SUPT4H1 fusion protein - ag8046 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human SUPT4H1 - SUPT4H1-31480TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human SUPT4H1 - SUPT4H1-31481TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human SUPT4H1, GST-tagged - SUPT4H1-3056H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Transcription elongation factor SPT4(spt-4) - CSB-YP733847CXX CSB-EP733847CXX CSB-BP733847CXX CSB-MP733847CXX from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Caenorhabditis

Recombinant Human Transcription elongation factor SPT4(SUPT4H1) - CSB-YP022957HU CSB-EP022957HU CSB-BP022957HU CSB-MP022957HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SUPT4H Blocking Peptide - CBP4266 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Monkey

SUPT4H Blocking Peptide - abx161477 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Monkey

SUPT4H1 Protein - abx164494 from Abbexa Category Protein Species Human, Mouse, Rat

SUPT4H1 - TP301211 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

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