| Gene Symbol |
TIGAR
|
| Entrez Gene |
57103
|
| Alt Symbol |
C12orf5, FR2BP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TP53 induced glycolysis regulatory phosphatase
|
| Other Description |
TP53-induced glycolysis and apoptosis regulator|fructose-2,6-bisphosphatase TIGAR|fructose-2,6-bisphosphate 2-phosphatase|probable fructose-2,6-bisphosphatase TIGAR|transactivated by NS3TP2 protein
|
| Swissprots |
Q9NQ88 B2R840
|
| Accessions |
EAW88849 EAW88850 Q9NQ88 AJ272206 CAC01127 AK313226 BAG36037 AM392615 CAL37493 AY425618 AAQ98969 BC012340 AAH12340 BX098281 DB480618 NM_020375 NP_065108
|
| Function |
Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53. {ECO:0000269|PubMed:16839880}.
|
| Top Pathways |
Central carbon metabolism in cancer, Fructose and mannose metabolism
|