| Gene Symbol |
ARHGEF18
|
| Entrez Gene |
23370
|
| Alt Symbol |
P114-RhoGEF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho/Rac guanine nucleotide exchange factor (GEF) 18
|
| Other Description |
114 kDa Rho-specific guanine nucleotide exchange factor|P114-RHO-GEF|Rho-specific guanine nucleotide exchange factor p114|Rho/Rac guanine nucleotide exchange factor 18|SA-RhoGEF|p114RhoGEF|rho guanine nucleotide exchange factor 18|septin-associated RhoGEF
|
| Swissprots |
Q6ZSZ5 A8MV62 Q6DD92 O60274 B5ME81
|
| Accessions |
Q6ZSZ5 AA609742 AA829883 AB011093 BAA25447 AK074372 AK127045 BAC86801 BC008016 BC014994 BC077721 AAH77721 BQ055909 BX404969 DB075637 XM_005272464 XP_005272521 XM_006722705 XP_006722768 XM_006722706 XP_006722769 XM_006722708 XP_006722771 XM_006722709 XP_006722772 XM_011527835 XP_011526137 XM_011527836 XP_011526138 XM_011527837 XP_011526139 XM_011527838 XP_011526140 XM_011527839 XP_011526141 XM_011527840 XP_011526142 XM_011527841 XP_011526143 NM_001130955 NP_001124427 NM_015318 NP_056133
|
| Function |
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15558029}. Note=Colocalizes with actin stress fibers.
|
| Tissue Specificity |
Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029}.
|