ARHGEF18

Gene Symbol	ARHGEF18
Entrez Gene	23370
Alt Symbol	P114-RhoGEF
Species	Human
Gene Type	protein-coding
Description	Rho/Rac guanine nucleotide exchange factor (GEF) 18
Other Description	114 kDa Rho-specific guanine nucleotide exchange factor|P114-RHO-GEF|Rho-specific guanine nucleotide exchange factor p114|Rho/Rac guanine nucleotide exchange factor 18|SA-RhoGEF|p114RhoGEF|rho guanine nucleotide exchange factor 18|septin-associated RhoGEF
Swissprots	Q6ZSZ5 A8MV62 Q6DD92 O60274 B5ME81
Accessions	Q6ZSZ5 AA609742 AA829883 AB011093 BAA25447 AK074372 AK127045 BAC86801 BC008016 BC014994 BC077721 AAH77721 BQ055909 BX404969 DB075637 XM_005272464 XP_005272521 XM_006722705 XP_006722768 XM_006722706 XP_006722769 XM_006722708 XP_006722771 XM_006722709 XP_006722772 XM_011527835 XP_011526137 XM_011527836 XP_011526138 XM_011527837 XP_011526139 XM_011527838 XP_011526140 XM_011527839 XP_011526141 XM_011527840 XP_011526142 XM_011527841 XP_011526143 NM_001130955 NP_001124427 NM_015318 NP_056133
Function	Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15558029}. Note=Colocalizes with actin stress fibers.
Tissue Specificity	Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human p114RhoGEF full length protein - ab132027 from Abcam Category Protein Source Wheat germ Species Human

Human p114RhoGEF peptide - ab23189 from Abcam Category Peptide Species Human

ARHGEF18 Antibody Blocking Peptide - LS-E5403 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ARHGEF18 Antibody Blocking Peptide - LS-E25638 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human p114RhoGEF Protein - H00023370-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ARHGEF18-Antibody-N-term-Blocking-Peptide - BP17912a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ARHGEF18 blocking peptide - GTX10152-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant human Rho guanine nucleotide exchange factor 18 protein (OPCA00581) - OPCA00581 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human ARHGEF18 protein - orb245239 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

ARHGEF18 Immunizing peptide - orb17528 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

p114RhoGEF Peptide - AC21-0469-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ARHGEF18 - H00023370-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ARHGEF18 - H00023370-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

P114-RHO-GEF Peptide - 46-122P from ProSci Category Peptide Species Human, Dog

ARHGEF18 fusion protein - Ag1749 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human ARHGEF18, GST-tagged - ARHGEF18-9836H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant human Rho guanine nucleotide exchange factor 18 protein - CSB-EP052754h CSB-BP052754h CSB-MP052754h from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Rho guanine nucleotide exchange factor 18(ARHGEF18) ,partial - CSB-YP744417HU CSB-EP744417HU CSB-BP744417HU CSB-MP744417HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Rho guanine nucleotide exchange factor 18(ARHGEF18) ,partial - CSB-RP052754h from Cusabio Category Protein Source E.coli Species Human

Rho guanine nucleotide exchange factor 18 protein - RPC141127 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

P114-RHO-GEF/ARHGEF18, Peptide - MBS425299 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Homo sapiens (Human) Rho guanine nucleotide exchange factor 18 - CSB-EP019681HU from Cusabio Category Protein Source E.coli Species Human

p114RhoGEF Protein - NBP1-92238PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ARHGEF18 Peptide, Human - M34GP00886H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant human Rho guanine nucleotide exchange factor 18 protein - AP71882 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

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