| Gene Symbol | ARHGEF18 |
|---|---|
| Entrez Gene | 23370 |
| Alt Symbol | P114-RhoGEF |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rho/Rac guanine nucleotide exchange factor (GEF) 18 |
| Other Description | 114 kDa Rho-specific guanine nucleotide exchange factor|P114-RHO-GEF|Rho-specific guanine nucleotide exchange factor p114|Rho/Rac guanine nucleotide exchange factor 18|SA-RhoGEF|p114RhoGEF|rho guanine nucleotide exchange factor 18|septin-associated RhoGEF |
| Swissprots | Q6ZSZ5 A8MV62 Q6DD92 O60274 B5ME81 |
| Accessions | Q6ZSZ5 AA609742 AA829883 AB011093 BAA25447 AK074372 AK127045 BAC86801 BC008016 BC014994 BC077721 AAH77721 BQ055909 BX404969 DB075637 XM_005272464 XP_005272521 XM_006722705 XP_006722768 XM_006722706 XP_006722769 XM_006722708 XP_006722771 XM_006722709 XP_006722772 XM_011527835 XP_011526137 XM_011527836 XP_011526138 XM_011527837 XP_011526139 XM_011527838 XP_011526140 XM_011527839 XP_011526141 XM_011527840 XP_011526142 XM_011527841 XP_011526143 NM_001130955 NP_001124427 NM_015318 NP_056133 |
| Function | Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15558029}. Note=Colocalizes with actin stress fibers. |
| Tissue Specificity | Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. {ECO:0000269|PubMed:11085924, ECO:0000269|PubMed:14512443, ECO:0000269|PubMed:15558029}. |
ARHGEF18 CRISPR/Cas9 KO Plasmid (h) - sc-407773 from Santa Cruz Biotechnology
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ARHGEF18 HDR Plasmid (h) - sc-407773-HDR from Santa Cruz Biotechnology
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ARHGEF18 Double Nickase Plasmid (h) - sc-407773-NIC from Santa Cruz Biotechnology
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ARHGEF18 Double Nickase Plasmid (h2) - sc-407773-NIC-2 from Santa Cruz Biotechnology
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ARHGEF18 CRISPR Activation Plasmid (h) - sc-407773-ACT from Santa Cruz Biotechnology
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ARHGEF18 CRISPR Activation Plasmid (h2) - sc-407773-ACT-2 from Santa Cruz Biotechnology
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ARHGEF18 Lentiviral Activation Particles (h) - sc-407773-LAC from Santa Cruz Biotechnology
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ARHGEF18 Lentiviral Activation Particles (h2) - sc-407773-LAC-2 from Santa Cruz Biotechnology
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ARHGEF18 siRNA (h) - sc-97769 from Santa Cruz Biotechnology
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ARHGEF18 shRNA Plasmid (h) - sc-97769-SH from Santa Cruz Biotechnology
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ARHGEF18 shRNA (h) Lentiviral Particles - sc-97769-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU063871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3449 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3449 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10913 from Sigma-Aldrich
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ARHGEF18 siRNA (Human) - CRH8218 from Cohesion Biosciences
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ARHGEF18 - MBS8225891 from MyBioSource
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shRNA set against Human ARHGEF18 (NM_015318.3) - SHH239758 from Creative biogene
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Human ARHGEF18 siRNA - orb268720 from Biorbyt
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ARHGEF18 shRNA Plasmid (Human) - CHH8218 from Cohesion Biosciences
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ARHGEF18 miRNA 3'UTR clone - MiUTR3H-13613 from Creative biogene
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ARHGEF18 miRNA 3'UTR clone - MiUTR3H-13614 from Creative biogene
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