| Gene Symbol |
BMPR1A
|
| Entrez Gene |
657
|
| Alt Symbol |
10q23del, ACVRLK3, ALK3, CD292, SKR5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
bone morphogenetic protein receptor, type IA
|
| Other Description |
ALK-3|BMP type-1A receptor|BMPR-1A|activin A receptor, type II-like kinase 3|activin receptor-like kinase 3|bone morphogenetic protein receptor type-1A|serine/threonine-protein kinase receptor R5
|
| Swissprots |
Q8NEN8 A8K6U9 P36894
|
| Accessions |
CBY84973 EAW80320 P36894 AB451405 BAG70219 AK291764 BAF84453 BC028383 AAH28383 BM819272 DQ786215 DQ891524 ABM82450 DQ894714 ABM85640 Z22535 CAA80257 XM_011540103 XP_011538405 XM_011540104 XP_011538406 NM_004329 NP_004320
|
| Function |
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Highly expressed in skeletal muscle.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells
|
