Gene Symbol | BMPR1A |
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Entrez Gene | 657 |
Alt Symbol | 10q23del, ACVRLK3, ALK3, CD292, SKR5 |
Species | Human |
Gene Type | protein-coding |
Description | bone morphogenetic protein receptor, type IA |
Other Description | ALK-3|BMP type-1A receptor|BMPR-1A|activin A receptor, type II-like kinase 3|activin receptor-like kinase 3|bone morphogenetic protein receptor type-1A|serine/threonine-protein kinase receptor R5 |
Swissprots | Q8NEN8 A8K6U9 P36894 |
Accessions | CBY84973 EAW80320 P36894 AB451405 BAG70219 AK291764 BAF84453 BC028383 AAH28383 BM819272 DQ786215 DQ891524 ABM82450 DQ894714 ABM85640 Z22535 CAA80257 XM_011540103 XP_011538405 XM_011540104 XP_011538406 NM_004329 NP_004320 |
Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Highly expressed in skeletal muscle. |
Top Pathways | Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells |
Active human BMPR1A (mutated R486 Q) protein fragment - ab201403 from Abcam
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Active human BMPR1A protein fragment - ab105907 from Abcam
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Active human BMPR1A protein fragment - ab123844 from Abcam
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Active human BMPR1A protein fragment - ab201369 from Abcam
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Active human BMPR1A protein fragment - ab157350 from Abcam
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Human BMPR1A full length protein - ab131986 from Abcam
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Human BMPR1A protein fragment - ab157341 from Abcam
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Human BMPR1A protein fragment - ab157970 from Abcam
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Human BMPR1A protein fragment - ab185408 from Abcam
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Human BMPR1A protein fragment - ab55202 from Abcam
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ALK3 / BMPR1A Antibody Blocking Peptide - LS-E4217 from LifeSpan Bioscience
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ALK3 / BMPR1A Antibody Blocking Peptide - LS-E6792 from LifeSpan Bioscience
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ALK3 / BMPR1A Antibody Blocking Peptide - LS-E6793 from LifeSpan Bioscience
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ALK3 / BMPR1A Antibody Blocking Peptide - LS-E6794 from LifeSpan Bioscience
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ALK3 / BMPR1A Antibody Blocking Peptide - LS-E6795 from LifeSpan Bioscience
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ALK3 / BMPR1A Antibody Blocking Peptide - LS-E6796 from LifeSpan Bioscience
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ALK3 / BMPR1A Antibody Blocking Peptide - LS-E26072 from LifeSpan Bioscience
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BMPR-IA/ALK-3 Recombinant Protein - H00000657-P01 from Novus Biologicals
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BMPR-IA/ALK-3 Partial Recombinant Protein - H00000657-Q01 from Novus Biologicals
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BMPR-IA/ALK-3 Recombinant Protein - P4155 from Novus Biologicals
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BMPR-IA/ALK-3 Protein - NBP1-99582 from Novus Biologicals
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BMPR-IA/ALK-3 Recombinant Protein - H00000657-G01 from Novus Biologicals
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BMPR-IA/ALK-3 Peptide - P0793 from Novus Biologicals
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BMPR-IA/ALK-3 Peptide - P0792 from Novus Biologicals
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BMPR-IA/ALK-3 Peptide - P0791 from Novus Biologicals
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