| Gene Symbol |
TCEAL7
|
| Entrez Gene |
56849
|
| Alt Symbol |
MPMGp800C04260Q003, WEX5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription elongation factor A (SII)-like 7
|
| Other Description |
TCEA-like protein 7|transcription elongation factor A protein-like 7|transcription elongation factor S-II protein-like 7
|
| Swissprots |
B3KSV2 Q9BRU2 Q96AT4
|
| Accessions |
EAW54714 Q9BRU2 AJ297363 CAB95948 AK094400 BAG52864 BC005988 AAH05988 BC016786 AAH16786 DA142141 DB481725 EU446610 ABZ92139 EU446623 ABZ92152 NM_152278 NP_689491
|
| Function |
Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines. {ECO:0000269|PubMed:18806825, ECO:0000269|PubMed:19966855, ECO:0000269|PubMed:20454512}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:18806825}.
|
| Tissue Specificity |
Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors. {ECO:0000269|PubMed:18806825}.
|