Gene Symbol | TCEAL7 |
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Entrez Gene | 56849 |
Alt Symbol | MPMGp800C04260Q003, WEX5 |
Species | Human |
Gene Type | protein-coding |
Description | transcription elongation factor A (SII)-like 7 |
Other Description | TCEA-like protein 7|transcription elongation factor A protein-like 7|transcription elongation factor S-II protein-like 7 |
Swissprots | B3KSV2 Q9BRU2 Q96AT4 |
Accessions | EAW54714 Q9BRU2 AJ297363 CAB95948 AK094400 BAG52864 BC005988 AAH05988 BC016786 AAH16786 DA142141 DB481725 EU446610 ABZ92139 EU446623 ABZ92152 NM_152278 NP_689491 |
Function | Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines. {ECO:0000269|PubMed:18806825, ECO:0000269|PubMed:19966855, ECO:0000269|PubMed:20454512}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18806825}. |
Tissue Specificity | Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors. {ECO:0000269|PubMed:18806825}. |
TCEAL7 Antibody Blocking Peptide - LS-E18339 from LifeSpan Bioscience
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Recombinant Human TCEAL7 Protein - NBP1-98915 from Novus Biologicals
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Human TCEAL7 protein - orb169403 from Biorbyt
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TCEAL7 protein (His tag) - 80R-2355 from Fitzgerald
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TCEAL7 (1-100, His-tag) - AR50440PU-N from Acris Antibodies
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TCEAL7 (1-100, His-tag) - AR50440PU-S from Acris Antibodies
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TCEAL7, 1-100aa, Human, His tag, E.coli - 01-P1616 from ARP American Research Products
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TCEAL7 fusion protein - ag1715 from Proteintech Group
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TCEAL7, 1-100aa, Recombinant Protein - GWB-P0422F from Genway Biotech
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Recombinant Human Transcription Elongation Factor A (SII)-Like 7, His-tagged - TCEAL7-6856H from Creative Biomart
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Recombinant Human TCEAL7 - TCEAL7-436H from Creative Biomart
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Recombinant Human Transcription elongation factor A protein-like 7(TCEAL7) - CSB-YP863109HU CSB-EP863109HU CSB-BP863109HU CSB-MP863109HU from Cusabio
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TCEAL7, 1-100aa, Human, His tag, E.coli - ATGP1616 from ATGen
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TCEAL7, Recombinant Protein - MBS204233 from MyBioSource
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TCEAL7 Peptide, Human - M34GP15706H from Creative Peptides
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TCEAL7 Recombinant Protein Antigen - NBP2-30974PEP from Novus Biologicals
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TCEAL7 - PAT-81656-1 from Nordic BioSite
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TCEAL7 - PAT-81656-2 from Nordic BioSite
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TCEAL7 Recombinant Protein Antigen - NBP2-56168PEP from Novus Biologicals
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