| Gene Symbol |
GPR119
|
| Entrez Gene |
139760
|
| Alt Symbol |
GPCR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 119
|
| Other Description |
G-protein coupled receptor 2|glucose-dependent insulinotropic receptor
|
| Swissprots |
Q4VBN3 Q8TDV5 Q495H7
|
| Accessions |
BAB89297 BAC06151 CAM84963 Q8TDV5 AY288416 AAP72125 BC095502 AAH95502 BC101166 AAI01167 BC101167 AAI01168 BC101168 AAI01169 BC126179 AAI26180 BC126181 AAI26182 HQ258187 ADR82941 NM_178471 NP_848566
|
| Function |
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. {ECO:0000269|PubMed:16517404}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Predominantly expressed in the pancreas, especially in the islets. {ECO:0000269|PubMed:15607732}.
|
| Top Pathways |
cAMP signaling pathway
|