Gene Symbol | GPR119 |
---|---|
Entrez Gene | 139760 |
Alt Symbol | GPCR2 |
Species | Human |
Gene Type | protein-coding |
Description | G protein-coupled receptor 119 |
Other Description | G-protein coupled receptor 2|glucose-dependent insulinotropic receptor |
Swissprots | Q4VBN3 Q8TDV5 Q495H7 |
Accessions | BAB89297 BAC06151 CAM84963 Q8TDV5 AY288416 AAP72125 BC095502 AAH95502 BC101166 AAI01167 BC101167 AAI01168 BC101168 AAI01169 BC126179 AAI26180 BC126181 AAI26182 HQ258187 ADR82941 NM_178471 NP_848566 |
Function | Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. {ECO:0000269|PubMed:16517404}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Predominantly expressed in the pancreas, especially in the islets. {ECO:0000269|PubMed:15607732}. |
Top Pathways | cAMP signaling pathway |
GPR119 CRISPR/Cas9 KO Plasmid (h) - sc-403135 from Santa Cruz Biotechnology
|
||||||||
GPR119 HDR Plasmid (h) - sc-403135-HDR from Santa Cruz Biotechnology
|
||||||||
GPR119 Double Nickase Plasmid (h) - sc-403135-NIC from Santa Cruz Biotechnology
|
||||||||
GPR119 Double Nickase Plasmid (h2) - sc-403135-NIC-2 from Santa Cruz Biotechnology
|
||||||||
GPR119 CRISPR Activation Plasmid (h) - sc-403135-ACT from Santa Cruz Biotechnology
|
||||||||
GPR119 CRISPR Activation Plasmid (h2) - sc-403135-ACT-2 from Santa Cruz Biotechnology
|
||||||||
GPR119 Lentiviral Activation Particles (h) - sc-403135-LAC from Santa Cruz Biotechnology
|
||||||||
GPR119 Lentiviral Activation Particles (h2) - sc-403135-LAC-2 from Santa Cruz Biotechnology
|
||||||||
GPR119 siRNA (h) - sc-60733 from Santa Cruz Biotechnology
|
||||||||
GPR119 shRNA Plasmid (h) - sc-60733-SH from Santa Cruz Biotechnology
|
||||||||
GPR119 shRNA (h) Lentiviral Particles - sc-60733-V from Santa Cruz Biotechnology
|
||||||||
GPR119 RNAi - H00139760-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU139371 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN2565 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2565 from Sigma-Aldrich
|
||||||||
GPR119 siRNA (Human) - CRJ5266 from Cohesion Biosciences
|
||||||||
GPR119 - MBS8237526 from MyBioSource
|
||||||||
shRNA set against Human GPR119 (NM_178471.2) - SHH306146 from Creative biogene
|
||||||||
Human GPR119 siRNA - orb275767 from Biorbyt
|
||||||||
GPR119 shRNA Plasmid (Human) - CHJ5266 from Cohesion Biosciences
|
||||||||
GPR119 miRNA 3'UTR clone - MiUTR4H-TG03952 from Creative biogene
|