| Gene Symbol |
VTA1
|
| Entrez Gene |
51534
|
| Alt Symbol |
C6orf55, DRG-1, DRG1, HSPC228, LIP5, My012, SBP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vesicle (multivesicular body) trafficking 1
|
| Other Description |
LYST-interacting protein 5|SKD1-binding protein 1|Vps20-associated 1 homolog|dopamine-responsive gene 1 protein|homolog of mouse SKD1-binding protein 1|vacuolar protein sorting-associated protein VTA1 homolog
|
| Swissprots |
Q9P0Q0 Q5TGM1 B4DW55 Q9H3K9 Q9NP79 Q6IAE8 Q9H0R2 E7ETQ7 E1P594
|
| Accessions |
EAW47883 EAW47884 EAW47885 Q9NP79 AF060225 AAG43125 AF141341 AAG49444 AF151062 AAF36148 AF271994 AAF76210 AJ420507 AK000051 BAA90909 AK130738 AK301376 BAG62917 AL136684 CAB66619 AY007093 BC005937 AAH05937 BC006989 AAH06989 BC013217 BC022536 AAH22536 BM806661 CR457207 CAG33488 DA299959 DQ893520 ABM84446 DQ896504 ABM87503 NM_001286371 NP_001273300 NM_001286372 NP_001273301 NM_016485 NP_057569
|
| Function |
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding. {ECO:0000250, ECO:0000269|PubMed:15644320}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15644320}. Endosome membrane {ECO:0000305|PubMed:15644320}; Peripheral membrane protein {ECO:0000305|PubMed:15644320}.
|
| Top Pathways |
Endocytosis
|