VTA1

Gene Symbol VTA1
Entrez Gene 51534
Alt Symbol C6orf55, DRG-1, DRG1, HSPC228, LIP5, My012, SBP1
Species Human
Gene Type protein-coding
Description vesicle (multivesicular body) trafficking 1
Other Description LYST-interacting protein 5|SKD1-binding protein 1|Vps20-associated 1 homolog|dopamine-responsive gene 1 protein|homolog of mouse SKD1-binding protein 1|vacuolar protein sorting-associated protein VTA1 homolog
Swissprots Q9P0Q0 Q5TGM1 B4DW55 Q9H3K9 Q9NP79 Q6IAE8 Q9H0R2 E7ETQ7 E1P594
Accessions EAW47883 EAW47884 EAW47885 Q9NP79 AF060225 AAG43125 AF141341 AAG49444 AF151062 AAF36148 AF271994 AAF76210 AJ420507 AK000051 BAA90909 AK130738 AK301376 BAG62917 AL136684 CAB66619 AY007093 BC005937 AAH05937 BC006989 AAH06989 BC013217 BC022536 AAH22536 BM806661 CR457207 CAG33488 DA299959 DQ893520 ABM84446 DQ896504 ABM87503 NM_001286371 NP_001273300 NM_001286372 NP_001273301 NM_016485 NP_057569
Function Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding. {ECO:0000250, ECO:0000269|PubMed:15644320}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15644320}. Endosome membrane {ECO:0000305|PubMed:15644320}; Peripheral membrane protein {ECO:0000305|PubMed:15644320}.
Top Pathways Endocytosis

VTA1-Over-expression-Lysate - LY14623a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag VTA1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 43) or transiently transfected with theVTA1 gene.

VTA1 overexpression lysate - LY413927 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

VTA1 293 Cell Lysate - 406687 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

VTA1 Overexpression Lysate (Native) - NBL1-17767 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: VTA1 Overexpression Lysate (Adult Normal) [NBL1-17767] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for VTA1.

LIP5 (h): 293 Lysate - sc-173648 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

VTA1 Over-expression Lysate Product - GWB-1339F9 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human VTA1 Knockdown Stable Cell Line - CSC-DC017352 from Creative biogene

Category Cell Line
Species Human
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