| Gene Symbol |
IYD
|
| Entrez Gene |
389434
|
| Alt Symbol |
C6orf71, DEHAL1, TDH4, dJ422F24.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
iodotyrosine deiodinase
|
| Other Description |
IYD-1|iodotyrosine dehalogenase 1
|
| Swissprots |
Q7Z7D7 C9JFW2 Q5F1L5 Q7Z7D8 Q5THM4 Q6ZP69 Q2VPW0 Q2VPW1 Q5F1L6 Q6PHW0
|
| Accessions |
EAW47769 Q6PHW0 AI823392 AK129950 BAC85255 AY259176 AAP22072 AY259177 AAP22073 AY424901 AAR84259 AY424902 AAR84260 AY957659 AAY41465 AY957660 AAY41466 AY957661 AAY41467 AY957662 AAY41468 BC056253 AAH56253 HQ447635 ADQ32120 XM_006715478 XP_006715541 XM_006715479 XP_006715542 XR_245516 NM_001164694 NP_001158166 NM_001164695 NP_001158167 NM_203395 NP_981932
|
| Function |
Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. {ECO:0000269|PubMed:15289438}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15289438}; Single-pass membrane protein {ECO:0000269|PubMed:15289438}.
|
| Tissue Specificity |
Expressed at a high level in thyroid gland and at lower level in kidney and trachea. {ECO:0000269|PubMed:15289438}.
|
| Top Pathways |
Thyroid hormone synthesis
|
