PPBP
| Gene Symbol | PPBP |
|---|---|
| Entrez Gene | 5473 |
| Alt Symbol | B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) |
| Other Description | C-X-C motif chemokine 7|CXC chemokine ligand 7|beta-thromboglobulin|connective tissue-activating peptide III|leukocyte-derived growth factor|low-affinity platelet factor IV|macrophage-derived growth factor|neutrophil-activating peptide 2|neutrophil-activating peptide-2|platelet basic protein|small inducible cytokine B7|small inducible cytokine subfamily B, member 7|small-inducible cytokine B7|thrombocidin 1|thrombocidin 2|thromboglobulin, beta-1 |
| Swissprots | P02775 Q6IBJ8 B2R5F3 |
| Accessions | AAB46877 AAK29642 AAY41004 ADB85518 ADB85519 ADB85520 EAX05695 P02775 AK312166 BAG35100 BC028217 AAH28217 BQ447470 BX443846 CB112845 CR456805 CAG33086 DA419455 DQ891020 ABM81946 DQ894200 ABM85126 M54995 AAA62836 NM_002704 NP_002695 |
| Function | LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}. |
| Subcellular Location | Secreted. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
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