PPBP

Gene Symbol	PPBP
Entrez Gene	5473
Alt Symbol	B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1
Species	Human
Gene Type	protein-coding
Description	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Other Description	C-X-C motif chemokine 7|CXC chemokine ligand 7|beta-thromboglobulin|connective tissue-activating peptide III|leukocyte-derived growth factor|low-affinity platelet factor IV|macrophage-derived growth factor|neutrophil-activating peptide 2|neutrophil-activating peptide-2|platelet basic protein|small inducible cytokine B7|small inducible cytokine subfamily B, member 7|small-inducible cytokine B7|thrombocidin 1|thrombocidin 2|thromboglobulin, beta-1
Swissprots	P02775 Q6IBJ8 B2R5F3
Accessions	AAB46877 AAK29642 AAY41004 ADB85518 ADB85519 ADB85520 EAX05695 P02775 AK312166 BAG35100 BC028217 AAH28217 BQ447470 BX443846 CB112845 CR456805 CAG33086 DA419455 DQ891020 ABM81946 DQ894200 ABM85126 M54995 AAA62836 NM_002704 NP_002695
Function	LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}.
Subcellular Location	Secreted.
Top Pathways	Cytokine-cytokine receptor interaction, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PBP CRISPR/Cas9 KO Plasmid (h) - sc-418259 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PBP HDR Plasmid (h) - sc-418259-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PBP Double Nickase Plasmid (h) - sc-418259-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PBP Double Nickase Plasmid (h2) - sc-418259-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PBP CRISPR Activation Plasmid (h) - sc-418259-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PBP CRISPR Activation Plasmid (h2) - sc-418259-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PBP Lentiviral Activation Particles (h) - sc-418259-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PBP Lentiviral Activation Particles (h2) - sc-418259-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PBP siRNA (h) - sc-39363 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PBP shRNA Plasmid (h) - sc-39363-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PBP shRNA (h) Lentiviral Particles - sc-39363-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CXCL7/NAP-2 RNAi - H00005473-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU041701 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17205 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17205 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00867 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr00867

PPBP siRNA (Human) - CRH3672 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CXCL7/NAP-2 RNAi - H00005473-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human PPBP (NM_002704.3) - SHH380396 from Creative biogene Category siRNA Species Reactivities Human

Human PPBP siRNA - orb264174 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PPBP shRNA Plasmid (Human) - CHH3672 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PPBP miRNA 3'UTR clone - MiUTR3H-00528 from Creative biogene Species Reactivities Human

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