PPBP

Gene Symbol	PPBP
Entrez Gene	5473
Alt Symbol	B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1
Species	Human
Gene Type	protein-coding
Description	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Other Description	C-X-C motif chemokine 7|CXC chemokine ligand 7|beta-thromboglobulin|connective tissue-activating peptide III|leukocyte-derived growth factor|low-affinity platelet factor IV|macrophage-derived growth factor|neutrophil-activating peptide 2|neutrophil-activating peptide-2|platelet basic protein|small inducible cytokine B7|small inducible cytokine subfamily B, member 7|small-inducible cytokine B7|thrombocidin 1|thrombocidin 2|thromboglobulin, beta-1
Swissprots	P02775 Q6IBJ8 B2R5F3
Accessions	AAB46877 AAK29642 AAY41004 ADB85518 ADB85519 ADB85520 EAX05695 P02775 AK312166 BAG35100 BC028217 AAH28217 BQ447470 BX443846 CB112845 CR456805 CAG33086 DA419455 DQ891020 ABM81946 DQ894200 ABM85126 M54995 AAA62836 NM_002704 NP_002695
Function	LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}.
Subcellular Location	Secreted.
Top Pathways	Cytokine-cytokine receptor interaction, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human NAP2 full length protein - ab192100 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Human

Human NAP2 full length protein - ab9556 from Abcam Category Protein Source E. coli Species Human

Human NAP2 full length protein - ab91094 from Abcam Category Protein Source Native Species Human

Human NAP2 full length protein - ab88021 from Abcam Category Protein Source Saccharomyces cerevisiae Species Human

Human NAP2 full length protein - ab198776 from Abcam Category Protein Source E. coli Species Human

Human NAP2 protein fragment - ab109834 from Abcam Category Protein Source E. coli Species Human

CXCL7 / PPBP Antibody Blocking Peptide - LS-E9050 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CXCL7 / PPBP Antibody Blocking Peptide - LS-E9051 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TCN2 Antibody Blocking Peptide - LS-E17411 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Human CXCL7/NAP-2 Protein - NBP2-35070 from Novus Biologicals Category Protein Prices $75.00 Sizes 2 µg Source Escherichia coli. Species Human

CXCL7/NAP-2 Recombinant Protein - H00005473-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CXCL7/NAP-2 Partial Recombinant Protein - H00005473-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CXCL7/NAP-2 Protein - NBP1-72355 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

CXCL7/NAP-2 Recombinant Protein - P4070 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Species Human

CXCL7/NAP-2 Recombinant Protein - P3656 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CXCL7/NAP-2 Protein - NBP1-99255 from Novus Biologicals Category Protein Prices $180.00 Sizes 10 µg Source E. coli Species Human

CXCL7/NAP-2 Peptide - P2567 from Novus Biologicals Category Peptide Species Human

PBP-PPBP-Antibody-C-term-Blocking-peptide - BP7556b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPBP-Antibody-N-term-Blocking-Peptide - BP7556a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NAP2 recombinant protein - GTX65205 from GeneTex Category Protein Prices $249.00 Sizes 10 μg Source E. coli Species Human

NAP-2 Recombinant Protein (Active) - GTX48173-PRO from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Human

Recombinant Human CXCL7/NAP-2 - 393-NP-010 from R&D Systems Category Protein Source E. coli-derived, Ala59-Asp128

Recombinant Human CXCL7/NAP-2 - 393-NP-050 from R&D Systems Category Protein Source E. coli-derived, Ala59-Asp128

Recombinant Human CXCL7/NAP-2, CF - 393-NP-010/CF from R&D Systems Category Protein Source E. coli-derived, Ala59-Asp128

Recombinant Human CXCL7/NAP-2, CF - 393-NP-050/CF from R&D Systems Category Protein Source E. coli-derived, Ala59-Asp128

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