| Gene Symbol |
HPSE2
|
| Entrez Gene |
60495
|
| Alt Symbol |
HPA2, HPR2, UFS, UFS1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heparanase 2 (inactive)
|
| Other Description |
heparanase 3|heparanase-like protein|inactive heparanase-2
|
| Swissprots |
Q5VUH6 Q8WWQ2 Q9HB39 Q9HB38 Q5VUH4 Q8WWQ1 Q5VUH5 Q9HB37
|
| Accessions |
AEC05334 EAW49872 EAW49873 EAW49874 Q8WWQ2 AF282885 AAG23421 AF282886 AAG23422 AF282887 AAG23423 AJ299719 CAC82491 AJ299720 CAC82492 AK021746 AK094037 BAG52801 AK126010 AK314759 BAG37297 BC112356 AAI12357 XM_006717937 XP_006718000 XM_011540029 XP_011538331 XM_011540030 XP_011538332 XM_011540031 XP_011538333 XM_011540032 XP_011538334 XM_011540033 XP_011538335 XR_945794 NM_001166244 NP_001159716 NM_001166245 NP_001159717 NM_001166246 NP_001159718 NM_021828 NP_068600
|
| Function |
Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). {ECO:0000269|PubMed:20576607}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20576607}.
|
| Tissue Specificity |
Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues. {ECO:0000269|PubMed:11027606, ECO:0000269|PubMed:20560210}.
|
| Top Pathways |
Proteoglycans in cancer, Glycosaminoglycan degradation
|