HPSE2

Gene Symbol	HPSE2
Entrez Gene	60495
Alt Symbol	HPA2, HPR2, UFS, UFS1
Species	Human
Gene Type	protein-coding
Description	heparanase 2 (inactive)
Other Description	heparanase 3|heparanase-like protein|inactive heparanase-2
Swissprots	Q5VUH6 Q8WWQ2 Q9HB39 Q9HB38 Q5VUH4 Q8WWQ1 Q5VUH5 Q9HB37
Accessions	AEC05334 EAW49872 EAW49873 EAW49874 Q8WWQ2 AF282885 AAG23421 AF282886 AAG23422 AF282887 AAG23423 AJ299719 CAC82491 AJ299720 CAC82492 AK021746 AK094037 BAG52801 AK126010 AK314759 BAG37297 BC112356 AAI12357 XM_006717937 XP_006718000 XM_011540029 XP_011538331 XM_011540030 XP_011538332 XM_011540031 XP_011538333 XM_011540032 XP_011538334 XM_011540033 XP_011538335 XR_945794 NM_001166244 NP_001159716 NM_001166245 NP_001159717 NM_001166246 NP_001159718 NM_021828 NP_068600
Function	Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). {ECO:0000269|PubMed:20576607}.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20576607}.
Tissue Specificity	Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues. {ECO:0000269|PubMed:11027606, ECO:0000269|PubMed:20560210}.
Top Pathways	Proteoglycans in cancer, Glycosaminoglycan degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HPSE2 protein fragment - ab127204 from Abcam Category Protein Source E. coli Species Human

Heparanase 2 / HPSE2 Antibody Blocking Peptide - LS-E2100 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Heparanase 2 / HPSE2 Antibody Blocking Peptide - LS-E23977 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HPSE2-Antibody-C-term-Blocking-peptide - BP12994c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HPSE2 fusion protein - ag15179 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

HPSE2 fusion protein - ag15526 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Heparanase-2(HPSE2) - CSB-YP823898HU CSB-EP823898HU CSB-BP823898HU CSB-MP823898HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HPSE2 Protein - abx163508 from Abbexa Category Protein Species Human, Mouse, Rat

HPSE2 Protein - NBP1-93691PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

HPSE2 Antibody - SH-A12742 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

HPSE2 Peptide, Human - M34GP07239H from Creative Peptides Category Peptide Source Synthetic. Species Human

Heparanase-2 (HPSE2), Recombinant Protein - MBS1459204 from MyBioSource Category Protein Prices $1,345.00, $1,345.00, $1,565.00, $1,565.00, $2,230.00, $2,230.00, $2,695.00, $2,695.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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