HPSE2

Gene Symbol HPSE2
Entrez Gene 60495
Alt Symbol HPA2, HPR2, UFS, UFS1
Species Human
Gene Type protein-coding
Description heparanase 2 (inactive)
Other Description heparanase 3|heparanase-like protein|inactive heparanase-2
Swissprots Q5VUH6 Q8WWQ2 Q9HB39 Q9HB38 Q5VUH4 Q8WWQ1 Q5VUH5 Q9HB37
Accessions AEC05334 EAW49872 EAW49873 EAW49874 Q8WWQ2 AF282885 AAG23421 AF282886 AAG23422 AF282887 AAG23423 AJ299719 CAC82491 AJ299720 CAC82492 AK021746 AK094037 BAG52801 AK126010 AK314759 BAG37297 BC112356 AAI12357 XM_006717937 XP_006718000 XM_011540029 XP_011538331 XM_011540030 XP_011538332 XM_011540031 XP_011538333 XM_011540032 XP_011538334 XM_011540033 XP_011538335 XR_945794 NM_001166244 NP_001159716 NM_001166245 NP_001159717 NM_001166246 NP_001159718 NM_021828 NP_068600
Function Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). {ECO:0000269|PubMed:20576607}.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20576607}.
Tissue Specificity Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues. {ECO:0000269|PubMed:11027606, ECO:0000269|PubMed:20560210}.
Top Pathways Proteoglycans in cancer, Glycosaminoglycan degradation

HPA2 (C-17) - sc-14900 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HPA2 (C-17): sc-14900. Western blot analysis of HPA2 expression in NCI-H1299 (A), HeLa (B), PC-3 (C), Jurkat (D) and CCRF-CEM (E) whole cell lysates.

HPA2 (H-100) - sc-30123 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HPA2 (H-100): sc-30123. Western blot analysis of HPA2 expression in NCI-H1299 (A), A549 (B), HeLa (C), Jurkat (D), CCRF-CEM (E) and RAW 264.7 (F) whole cell lysates.

HPA2 (N-19) - sc-14897 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HPA2 (N-19): sc-14897. Western blot analysis of HPA2 expression in Jurkat whole cell lysate.

Anti-HPSE2 antibody - ab97807 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HPSE2 antibody (ab97807) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : H1299 whole cell lysateLane 3 : HeLa S3 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-HPSE2 antibody - ab107603 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HPSE2 antibody (ab107603) at 1/500 dilutionLane 1 : 293T lysateLane 2 : HeLa lysateLane 3 : PC-3M1B8 lysateLane 4 : Human Fetal Brain lysateLane 5 : Human Fetal Intestine lysate

Anti-HPSE2 antibody - ab133853 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HPSE2 antibody (ab133853) at 1 µg/ml + Jurkat cell lysate at 10 µg

Anti-Heparanase 2 / HPSE2 Antibody (aa451-480, APC) - LS-C236397 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Heparanase 2 / HPSE2 Antibody (aa451-480, AP) - LS-C236398 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Heparanase 2 / HPSE2 Antibody (aa451-480, PE) - LS-C236402 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Heparanase 2 / HPSE2 Antibody (aa451-480, Biotin) - LS-C236399 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Heparanase 2 / HPSE2 Antibody (aa451-480, FITC) - LS-C236400 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Heparanase 2 / HPSE2 Antibody (aa451-480, Azide-free, HRP) - LS-C249226 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Heparanase 2 / HPSE2 Antibody (aa109-158) - LS-C152099 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Heparanase 2 / HPSE2 antibody Western Blot of Jurkat.

Anti-Heparanase 2 / HPSE2 Antibody (N-Terminus) - LS-C345803 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of HPSE2 Antibody with human MCF7 Whole Cell lysate.

Anti-Heparanase 2 / HPSE2 Antibody (aa451-480) - LS-C165007 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
HPSE2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-Heparanase 2 / HPSE2 Antibody (aa450-480) - LS-C322089 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Heparanase 2 / HPSE2 Antibody IHC-plus™ - LS-B4192 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-HPSE2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4192 concentration 10 ug/ml.

HPa2 Antibody (DHIC2-2B4) - NBP1-18950 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µl, 100 µl
Host Mouse
Clonality Monoclonal
Clone DHIC2-2B4

HPSE2 Antibody - NBP1-31457 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HPSE2 Antibody - NBP1-93691 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HPSE2 Antibody [NBP1-93691] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted)

ANTI-HPSE2 (C-TERM) antibody produced in rabbit - SAB1303451 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>HPSE2 (C-term): <B>Cat. No. SAB1303451</B>: HPSE2 in Human brain tissue with HPSE2 antibody (C-term) at 12.5 μg/mL.

Anti-HPSE2 antibody produced in rabbit - HPA044603 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HPSE2: <B>Cat. No. HPA044603</B>: Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.

Anti-HPSE2 antibody produced in rabbit - SAB2700219 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HPSE2: <B>Cat. No. SAB2700219</B>: Immunohistochemical analysis of paraffin-embedded Uterus, using HPA2 antibody at 1:100 dilution.

HPSE2 Antibody - N-terminal region (ARP65898_P050) - ARP65898_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HPSE2 Antibody - N-terminal region (ARP74572_P050) - ARP74572_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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