HPSE2

Gene Symbol HPSE2
Entrez Gene 60495
Alt Symbol HPA2, HPR2, UFS, UFS1
Species Human
Gene Type protein-coding
Description heparanase 2 (inactive)
Other Description heparanase 3|heparanase-like protein|inactive heparanase-2
Swissprots Q5VUH6 Q8WWQ2 Q9HB39 Q9HB38 Q5VUH4 Q8WWQ1 Q5VUH5 Q9HB37
Accessions AEC05334 EAW49872 EAW49873 EAW49874 Q8WWQ2 AF282885 AAG23421 AF282886 AAG23422 AF282887 AAG23423 AJ299719 CAC82491 AJ299720 CAC82492 AK021746 AK094037 BAG52801 AK126010 AK314759 BAG37297 BC112356 AAI12357 XM_006717937 XP_006718000 XM_011540029 XP_011538331 XM_011540030 XP_011538332 XM_011540031 XP_011538333 XM_011540032 XP_011538334 XM_011540033 XP_011538335 XR_945794 NM_001166244 NP_001159716 NM_001166245 NP_001159717 NM_001166246 NP_001159718 NM_021828 NP_068600
Function Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). {ECO:0000269|PubMed:20576607}.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20576607}.
Tissue Specificity Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues. {ECO:0000269|PubMed:11027606, ECO:0000269|PubMed:20560210}.
Top Pathways Proteoglycans in cancer, Glycosaminoglycan degradation

HPA2 CRISPR/Cas9 KO Plasmid (h) - sc-407826 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HPA2 HDR Plasmid (h) - sc-407826-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HPA2 Double Nickase Plasmid (h) - sc-407826-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HPA2 Double Nickase Plasmid (h2) - sc-407826-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HPA2 CRISPR Activation Plasmid (h) - sc-407826-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HPA2 CRISPR Activation Plasmid (h2) - sc-407826-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HPA2 Lentiviral Activation Particles (h) - sc-407826-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HPA2 Lentiviral Activation Particles (h2) - sc-407826-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HPA2 siRNA (h) - sc-43852 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HPA2 shRNA Plasmid (h) - sc-43852-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HPA2 shRNA (h) Lentiviral Particles - sc-43852-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU068351 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10285 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10285 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04040 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04040

HPSE2 siRNA (Human) - CRJ1808 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HPSE2 - MBS8238224 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human HPSE2 (NM_021828.4) - SHH314733 from Creative biogene

Category siRNA
Species Reactivities Human

Human HPSE2 siRNA - orb272309 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HPSE2 shRNA Plasmid (Human) - CHJ1808 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

HPSE2 miRNA 3'UTR clone - MiUTR4H-TG04298 from Creative biogene

Species Reactivities Human
Search more