CDH3

Gene Symbol CDH3
Entrez Gene 1001
Alt Symbol CDHP, HJMD, PCAD
Species Human
Gene Type protein-coding
Description cadherin 3, type 1, P-cadherin (placental)
Other Description cadherin-3|calcium-dependent adhesion protein, placental
Swissprots P22223 Q05DI6 B2R6F4
Accessions CAA65093 CAJ34555 CCQ77686 CCQ77695 CCQ77704 CCQ77713 CCV20012 CDH48192 CDH61614 CDH61668 CDH61687 CDH88985 CDH92523 CDH92537 CDH92548 CDH92795 CDH92892 CDI44667 CDI44676 EAW83237 EAW83238 EAW83239 P22223 AI149268 AK225396 AK296968 BAG59512 AK312554 BAG35451 BC014462 AAH14462 BC041846 AAH41846 BQ945506 BU543746 CA489015 CA489338 CA489357 CN365479 EU832319 ACE87576 EU832404 ACE86889 X63629 CAA45177 XM_011522800 XP_011521102 NM_001793 NP_001784
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in some normal epithelial tissues and in some carcinoma cell lines. {ECO:0000269|PubMed:2702654}.
Top Pathways Cell adhesion molecules (CAMs)

P-Cadherin Antibody - 2130 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot anlaysis of extracts from A431, Panc1 and HUVE cells, using P-Cadherin Antibody.

P-Cadherin (C13F9) Rabbit mAb - 2189 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C13F9
Western blot analysis of extracts from various cell types using P-Cadherin (C13F9) Rabbit mAb.

P-Cadherin (12H6) Mouse mAb - 14029 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 12H6
Western blot analysis of extracts from A-431 (positive) and MCF7 (negative) cells using P-Cadherin (12H6) Mouse mAb (upper) and Pan-Cadherin (28E12) Rabbit mAb #4073 (lower).

P-cadherin (H-105) - sc-7893 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
P-cadherin (H-105): sc-7893. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human placenta (A) and immunofluorescence staining of methanol-fixed JAR cells (B) showing membrane localization.

P-cadherin (A-10) - sc-74545 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
P-cadherin (A-10): sc-74545. Western blot analysis of P-cadherin expression in PC-3 (A), A-431 (B) and T84 (C) whole cell lysates.

P-cadherin (N-19) - sc-1501 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
P-cadherin (N-19): sc-1501. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human prostate carcinoma tissue showing membrane staining.

P-cadherin (6A9) - sc-33635 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
P-cadherin (6A9): sc-33635. Western blot analysis of P-cadherin expression in A-431 whole cell lysate.

P-cadherin (D-14) - sc-31027 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

P-cadherin (Y-17) - sc-31026 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

P-cadherin (12H6) - sc-53981 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
P-cadherin (12H6): sc-53981. Western blot analysis of P-cadherin expression in non-transfected: sc-117752 (A) and human P-cadherin transfected: sc-177672 (B) 293T whole cell lysates.

pan-cadherin (H-300) - sc-10733 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
pan-cadherin (H-300): sc-10733. Western blot analysis of cadherin expression in F9 whole cell lysate.

Anti-P cadherin antibody - ab65599 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-P cadherin antibody (ab65599) at 1/60 dilution + K562 cell line lysates at 35 µg

Anti-P cadherin antibody - ab111010 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-P cadherin antibody (ab111010) at 1 µg/mlLane 1 : Recombinant P cadherin protein at 0.01 µgLane 2 : Recombinant P cadherin protein at 0.005 µgLane 3 : Recombinant P cadherin protein at 0.0025 µgLane 4 : MK (55KD)

Anti-P cadherin antibody - ab75718 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab75718, at a dilution of 1/10, staining P cadherin in formalin fixed, paraffin embedded human prostate carcinoma tissue by Immunohistochemistry. ab75718 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

Anti-P cadherin antibody [56C1] - ab127577 from Abcam

Prices $370.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 56C1

Anti-P cadherin antibody [56C1], prediluted - ab75442 from Abcam

Prices $376.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone 56C1
Formalin-fixed, paraffin-embedded human tonsil stained with ab75442 using peroxidase conjugate and AEC chromogen. Note membrane staining of epithelial cells.

Anti-P cadherin antibody [6A9] - ab19350 from Abcam

Prices $373.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6A9
All lanes : Anti-P cadherin antibody [6A9] (ab19350) at 1/500 dilutionLane 1 : 293T cell lysateLane 2 : A431 cell lysateLane 3 : Mouse brain tissue lysateLysates/proteins at 25 µg per lane.SecondaryHRP-conjugated anti-mouse IgG

Anti-P cadherin antibody [MM0508-9V11] - ab89900 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0508-9V11
Overlay histogram showing A431 cells stained with ab89900 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab89900, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-P cadherin antibody [NCC-CAD-299] - ab12222 from Abcam

Prices $379.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone NCC-CAD-299
Overlay histogram showing A431 cells stained with ab12222 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab12222, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive signal in A431 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-P cadherin antibody - N-terminal - ab190076 from Abcam

Prices $384.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-P cadherin antibody - N-terminal (ab190076) at 1/1000 dilution + NIH 3T3 cell lysate at 35 µg

Anti-pan Cadherin antibody - ab6529 from Abcam

Prices $400.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent imaging of human cells (U2OS) with ab6529 confirms the specificity of this antibody.  Pan cadherin antibody recognises predominantly membranous signal with some fainter cytoplasmic staining corresponding to soluble cadherin. No nuclear staining is seen. IF was performed with a standard paraformaldehyde technique (fixed in PBS buffered PFH 4% for 5 minutes, permeabilised with 0.5% triton-PBS for 5 minutes, blocked with 5% milk / 0.2% tween for one hour.  Primary antibody used at 1/100 in 5% milk / 0.2% TWEEN for one hour, secondary antibody for 30 minutes.  All blocking and incubation steps carried out at 37 degrees C. Nuclei were stained with Hoechst stain.

Anti-pan Cadherin antibody - ab140338 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human skin tissue labelling pan Cadherin with ab140338 antibody at a dilution of 1/200.

Anti-pan Cadherin antibody - ab74635 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed, paraffin-embedded human lung small cell carcinoma stained with ab74635 at 5µg/ml using peroxidase-conjugate and AEC chromogen. Note membrane staining of tumor cells.

Anti-pan Cadherin antibody - ab45009 from Abcam

Prices $370.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-pan Cadherin antibody [CH-19] - ab6528 from Abcam

Prices $400.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone CH-19
Immunofluorescent imaging of human cells (U2OS) with ab6528 reveals the expected highly specific membranous distribution. IF was performed with a standard paraformaldehyde technique (fixed in PBS buffered PFH 4% for 5 minutes, permeabilised with 0.5% triton-PBS for 5 minutes, blocked with 5% milk / 0.2% tween for one hour. Primary antibody used at 1/100 in 5% milk / 0.2% TWEEN for one hour, secondary antibody for 30 minutes.  All blocking and incubation steps carried out at 37 degrees C.
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