CHMP2B

Gene Symbol	CHMP2B
Entrez Gene	25978
Alt Symbol	ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 2B
Other Description	VPS2 homolog B|charged multivesicular body protein 2b|chromatin modifying protein 2B|vacuolar protein-sorting-associated protein 2-2
Swissprots	Q53HC7 Q9Y4U6 Q9UQN3 B4DJG8
Accessions	EAW68868 Q9UQN3 AF151842 AAD34079 AK002165 BAG51022 AK002180 BAG51025 AK222654 BAD96374 AK296072 BAG58830 AK316585 BAG38173 AL080122 CAB45721 BC001553 AAH01553 BI821848 BM828410 BM982148 CR533456 CAG38487 DA426159 EU832121 ACE87471 EU832215 ACE86785 JF432605 ADZ15822 XM_011533576 XP_011531878 NM_001244644 NP_001231573 NM_014043 NP_054762
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:16041373}. Late endosome membrane {ECO:0000305|PubMed:16041373}; Peripheral membrane protein {ECO:0000305|PubMed:16041373}.
Tissue Specificity	Widely expressed. Expressed in brain, heart, skeletal muscle, spleen, kidney, liver, small intestine, pancreas, lung, placenta and leukocytes. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal chord, occipital lobe, frontal lobe, temporal lobe and putamen. {ECO:0000269|PubMed:16041373}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-CHMP2B-cDNA-Clone - DC00727 from Abgent, a WuXi AppTec company Prices $287.55 Sizes 10 µg Species Human Accession BC001553

CHMP2B - MBS1274660 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC001553

Human CHMP2B ORF Clone(NM_001244644.1) - CDCL158763 from Creative Biomart Species Human Accession NM_001244644.1

Human CHMP2B Gene ORF cDNA clone in cloning vector - HG14596-G from Sino Biological Species Human

Human CHMP2B Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14596-ACR from Sino Biological Species Human

Human CHMP2B Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14596-ANR from Sino Biological Species Human

Human CHMP2B Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14596-NF from Sino Biological Species Human

Human CHMP2B Gene ORF cDNA clone expression plasmid, N-His tag - HG14596-NH from Sino Biological Species Human

Human CHMP2B Gene ORF cDNA clone expression plasmid, N-HA tag - HG14596-NY from Sino Biological Species Human

Human CHMP2B Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14596-CF from Sino Biological Species Human

Human CHMP2B Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14596-ACG from Sino Biological Species Human

Human CHMP2B Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14596-NM from Sino Biological Species Human

Human CHMP2B Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14596-CM from Sino Biological Species Human

Human CHMP2B Gene ORF cDNA clone expression plasmid, C-His tag - HG14596-CH from Sino Biological Species Human

Human CHMP2B Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG14596-UT from Sino Biological Species Human Accession BC001553

Human CHMP2B Gene ORF cDNA clone expression plasmid, C-HA tag - HG14596-CY from Sino Biological Species Human

Human CHMP2B Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14596-ANG from Sino Biological Species Human

Human CHMP2B ORF clone (NM_001244644.1) - CDCR046818 from Creative biogene Species Human

Human CHMP2B ORF Clone (BC001553) - CDCS409908 from Creative biogene Species Human Accession Q9UQN3

Human CHMP2B ORF clone (BC001553) - CDCB158990 from Creative biogene Species Human

Human Charged multivesicular body protein 2b Gene - orb142504 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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