CHMP2B
| Gene Symbol | CHMP2B |
|---|---|
| Entrez Gene | 25978 |
| Alt Symbol | ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B |
| Species | Human |
| Gene Type | protein-coding |
| Description | charged multivesicular body protein 2B |
| Other Description | VPS2 homolog B|charged multivesicular body protein 2b|chromatin modifying protein 2B|vacuolar protein-sorting-associated protein 2-2 |
| Swissprots | Q53HC7 Q9Y4U6 Q9UQN3 B4DJG8 |
| Accessions | EAW68868 Q9UQN3 AF151842 AAD34079 AK002165 BAG51022 AK002180 BAG51025 AK222654 BAD96374 AK296072 BAG58830 AK316585 BAG38173 AL080122 CAB45721 BC001553 AAH01553 BI821848 BM828410 BM982148 CR533456 CAG38487 DA426159 EU832121 ACE87471 EU832215 ACE86785 JF432605 ADZ15822 XM_011533576 XP_011531878 NM_001244644 NP_001231573 NM_014043 NP_054762 |
| Function | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:16041373}. Late endosome membrane {ECO:0000305|PubMed:16041373}; Peripheral membrane protein {ECO:0000305|PubMed:16041373}. |
| Tissue Specificity | Widely expressed. Expressed in brain, heart, skeletal muscle, spleen, kidney, liver, small intestine, pancreas, lung, placenta and leukocytes. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal chord, occipital lobe, frontal lobe, temporal lobe and putamen. {ECO:0000269|PubMed:16041373}. |
| Top Pathways | Endocytosis |
CHMP2B CRISPR/Cas9 KO Plasmid (h) - sc-408849 from Santa Cruz Biotechnology
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CHMP2B HDR Plasmid (h) - sc-408849-HDR from Santa Cruz Biotechnology
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CHMP2B Double Nickase Plasmid (h) - sc-408849-NIC from Santa Cruz Biotechnology
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CHMP2B Double Nickase Plasmid (h2) - sc-408849-NIC-2 from Santa Cruz Biotechnology
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CHMP2B CRISPR Activation Plasmid (h) - sc-408849-ACT from Santa Cruz Biotechnology
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CHMP2B CRISPR Activation Plasmid (h2) - sc-408849-ACT-2 from Santa Cruz Biotechnology
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CHMP2B Lentiviral Activation Particles (h) - sc-408849-LAC from Santa Cruz Biotechnology
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CHMP2B Lentiviral Activation Particles (h2) - sc-408849-LAC-2 from Santa Cruz Biotechnology
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CHMP2B siRNA (h) - sc-72895 from Santa Cruz Biotechnology
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CHMP2B shRNA Plasmid (h) - sc-72895-SH from Santa Cruz Biotechnology
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CHMP2B shRNA (h) Lentiviral Particles - sc-72895-V from Santa Cruz Biotechnology
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CHMP2B RNAi - H00025978-R01 from Novus Biologicals
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MISSION® esiRNA - EHU000821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6071 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09909 from Sigma-Aldrich
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CHMP2B siRNA (Human) - CRH8629 from Cohesion Biosciences
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CHMP2B - MBS8217713 from MyBioSource
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shRNA set against Human CHMP2B (NM_014043.3) - SHH263201 from Creative biogene
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Human CHMP2B siRNA - orb269131 from Biorbyt
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CHMP2B shRNA Plasmid (Human) - CHH8629 from Cohesion Biosciences
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CHMP2B miRNA 3'UTR clone - MiUTR3H-10654 from Creative biogene
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