CHMP2B

Gene Symbol	CHMP2B
Entrez Gene	25978
Alt Symbol	ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 2B
Other Description	VPS2 homolog B|charged multivesicular body protein 2b|chromatin modifying protein 2B|vacuolar protein-sorting-associated protein 2-2
Swissprots	Q53HC7 Q9Y4U6 Q9UQN3 B4DJG8
Accessions	EAW68868 Q9UQN3 AF151842 AAD34079 AK002165 BAG51022 AK002180 BAG51025 AK222654 BAD96374 AK296072 BAG58830 AK316585 BAG38173 AL080122 CAB45721 BC001553 AAH01553 BI821848 BM828410 BM982148 CR533456 CAG38487 DA426159 EU832121 ACE87471 EU832215 ACE86785 JF432605 ADZ15822 XM_011533576 XP_011531878 NM_001244644 NP_001231573 NM_014043 NP_054762
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:16041373}. Late endosome membrane {ECO:0000305|PubMed:16041373}; Peripheral membrane protein {ECO:0000305|PubMed:16041373}.
Tissue Specificity	Widely expressed. Expressed in brain, heart, skeletal muscle, spleen, kidney, liver, small intestine, pancreas, lung, placenta and leukocytes. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal chord, occipital lobe, frontal lobe, temporal lobe and putamen. {ECO:0000269|PubMed:16041373}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CHMP2B full length protein - ab112405 from Abcam Category Protein Source Wheat germ Species Human

Human CHMP2B full length protein - ab109959 from Abcam Category Protein Source E. coli Species Human

Human CHMP2B peptide - ab27782 from Abcam Category Peptide

CHMP2B Antibody Blocking Peptide - LS-E2339 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHMP2B Antibody Blocking Peptide - LS-E19831 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHMP2B Recombinant Protein - H00025978-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CHMP2B Protein - NBP1-72361 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 100 µg, 500 µg Source E. coli Species Human

CHMP2B-Antibody-N-term-Blocking-peptide - BP13303a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CHMP2B Protein (OPPA00148) - OPPA00148 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human CHMP2B protein - orb168113 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

CHMP2B protein (His tag) - 80R-1873 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

CHMP2B (1-213, His-tag) - AR39055PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

CHMP2B (1-213, His-tag) - AR39055PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

CHMP2B - H00025978-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CHMP2B - H00025978-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CHMP2B, 1-213aa, Human, His tag, E.coli - 01-2146-B from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

CHMP2B fusion protein - Ag3222 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant Human Chromatin Modifying Protein 2B - BP001885-PRO-877 from Syd Labs Category Protein Prices $160.00, $3,600.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

CHMP2B, 1-213aa, Recombinant Protein - GWB-P0923M from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human CHMP2B, His-tagged - CHMP2B-3578H from Creative Biomart Category Protein

Recombinant Human Chromatin Modifying Protein 2B, His-tagged - CHMP2B-4985H from Creative Biomart Category Protein Source Human

Recombinant Human CHMP2B - CHMP2B-27996TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human CHMP2B, His-tagged - CHMP2B-27997TH from Creative Biomart Category Protein Source E. coli

Recombinant Human CHMP2B, His-tagged - CHMP2B-11185H from Creative Biomart Category Protein Source E.coli Species Human

CHMP2B 1-213aa - CMB-948 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

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