CHMP2B

Gene Symbol	CHMP2B
Entrez Gene	25978
Alt Symbol	ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 2B
Other Description	VPS2 homolog B|charged multivesicular body protein 2b|chromatin modifying protein 2B|vacuolar protein-sorting-associated protein 2-2
Swissprots	Q53HC7 Q9Y4U6 Q9UQN3 B4DJG8
Accessions	EAW68868 Q9UQN3 AF151842 AAD34079 AK002165 BAG51022 AK002180 BAG51025 AK222654 BAD96374 AK296072 BAG58830 AK316585 BAG38173 AL080122 CAB45721 BC001553 AAH01553 BI821848 BM828410 BM982148 CR533456 CAG38487 DA426159 EU832121 ACE87471 EU832215 ACE86785 JF432605 ADZ15822 XM_011533576 XP_011531878 NM_001244644 NP_001231573 NM_014043 NP_054762
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:16041373}. Late endosome membrane {ECO:0000305|PubMed:16041373}; Peripheral membrane protein {ECO:0000305|PubMed:16041373}.
Tissue Specificity	Widely expressed. Expressed in brain, heart, skeletal muscle, spleen, kidney, liver, small intestine, pancreas, lung, placenta and leukocytes. In brain, it is expressed in cerebellum, cerebral cortex, medulla, spinal chord, occipital lobe, frontal lobe, temporal lobe and putamen. {ECO:0000269|PubMed:16041373}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHMP2B (C-18) - sc-69350 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CHMP2B (D-20) - sc-69351 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CHMP2B (H-107) - sc-98550 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

CHMP2B (N-18) - sc-69352 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CHMP2B antibody - ab33174 from Abcam Prices $401.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CHMP2B antibody - ab76332 from Abcam Host Rabbit Clonality Polyclonal

Anti-CHMP2B antibody - ab153854 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B antibody - ab126200 from Abcam Prices $376.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B antibody - ab129235 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B antibody - ab135190 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CHMP2B antibody - ab133920 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B antibody [EPR10807(B)] - ab157208 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR10807(B)

Anti-CHMP2B Antibody (C-Terminus) - LS-C145188 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B Antibody - LS-C153393 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CHMP2B Antibody (aa1-30, APC) - LS-C233793 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B Antibody (aa2-213) - LS-C182812 from LifeSpan Bioscience Prices $650.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-CHMP2B Antibody (aa1-30, AP) - LS-C233794 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B Antibody (aa1-30, Biotin) - LS-C233795 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B Antibody (aa1-30, FITC) - LS-C233796 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B Antibody (N-Terminus) - LS-C151314 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CHMP2B Antibody (aa1-30, PE) - LS-C233797 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B Antibody - LS-C341789 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CHMP2B Antibody (aa1-30, Azide-free, HRP) - LS-C249666 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B Antibody (aa1-30) - LS-C329373 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP2B Antibody (clone 2H6-1E6) - LS-C306948 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2H6-1E6

Search more