SRD5A2

Gene Symbol SRD5A2
Entrez Gene 6716
Alt Symbol -
Species Human
Gene Type protein-coding
Description steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Other Description 3-oxo-5-alpha-steroid 4-dehydrogenase 2|5 alpha-SR2|S5AR 2|SR type 2|steroid 5-alpha-reductase 2|type II 5-alpha reductase
Swissprots P31213 Q2M1R4 Q9BYE6 B2RE87
Accessions AAW56942 BAB40419 EAX00478 P31213 AK307235 AK316597 BAG38184 BC112252 AAI12253 BC113641 AAI13642 EF560740 ABQ59050 EU832809 ACE87820 GQ129244 ACT64378 HQ258121 ADR82875 M74047 AAA60586 XM_011533068 XP_011531370 XM_011533069 XP_011531371 XM_011533070 XP_011531372 XM_011533071 XP_011531373 XM_011533072 XP_011531374 NM_000348 NP_000339
Function Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Subcellular Location Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed in high levels in the prostate and many other androgen-sensitive tissues.
Top Pathways Steroid hormone biosynthesis, Prostate cancer

5α-Reductase 2 (H-100) - sc-20659 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

5α-Reductase 2 (N-14) - sc-20400 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
5α-Reductase 2 (N-14): sc-20400. Immunoperoxidase staining of formalin fixed, paraffin-embedded human upper stomach tissue showing cytoplasmic staining of glandular cells.

5α-Reductase 2 (T-13) - sc-20404 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SRD5A2 antibody - ab27469 from Abcam

Prices $382.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-SRD5A2 antibody (ab27469) at 0.3 µg/ml + Human testes lysate (35ug protein in RIPA buffer)

Anti-SRD5A2 antibody - ab101896 from Abcam

Host Rabbit
Clonality Polyclonal
ICC/IF image of ab101896 stained CACO-2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab101896 at 1/200 dilution overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-SRD5A2 antibody - ab61276 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SRD5A2 antibody - ab99065 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SRD5A2 antibody (ab99065) at 1 µg/ml + THP-1 cell lysate at 10 µg

Anti-SRD5A2 antibody [EPR6281(B)] - ab124877 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6281(B)
All lanes : Anti-SRD5A2 antibody [EPR6281(B)] (ab124877) at 1/1000 dilutionLane 1 : LnCaP cell lysateLane 2 : Human testis lysateLane 3 : PC3 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SRD5A2 Antibody (aa227-249) - LS-C56449 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2 Antibody (aa227-249) - LS-C122448 from LifeSpan Bioscience

Prices $575.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2 Antibody (aa153-182, AP) - LS-C270325 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2 Antibody (aa153-182, APC) - LS-C270326 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2 Antibody (aa153-182) - LS-C161491 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SRD5A2 Antibody western blot of mouse kidney tissue lysates (15 ug/lane). The SRD5A2 antibody detected SRD5A2 protein (arrow).

Anti-SRD5A2 Antibody (aa153-182, Biotin) - LS-C270327 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2 Antibody (aa153-182, Azide-free, HRP) - LS-C270328 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2 Antibody (aa153-182, FITC) - LS-C270329 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2 Antibody (aa153-182, PE) - LS-C270331 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2 Antibody (aa160-190) - LS-C325373 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2 Antibody (aa1-43) - LS-C311573 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SRD5A2 Antibody (N-Terminus) - LS-C110928 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SRD5A2 antibody LS-C110928 Western blot of THP-1 cell lysate.

Anti-SRD5A2 Antibody (N-Terminus, clone EPR6281(B)) - LS-C138897 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6281(B)
Western blot analysis on (A) LnCaP, (B) human testis, and (C) PC-3 cell lysates using anti-SRD5A2 antibody.

Anti-SRD5A2 Antibody (aa2-13) - LS-C55528 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.3 ug/ml) staining of human testes lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SRD5A2 Antibody (aa35-84) - LS-C116260 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SRD5A2 antibody LS-C116260 Western blot of HepG2 cell lysate.

Anti-SRD5A2 Antibody (clone 1F4) - LS-C198258 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F4
Detection limit for recombinant GST tagged SRD5A2 is 0.03 ng/ml as a capture antibody.

Anti-SRD5A2 Antibody (aa237-247) - LS-C112720 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
SRD5A2 antibody (1 ug/ml) staining of Human Testis lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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