| Gene Symbol |
SRD5A2
|
| Entrez Gene |
6716
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
|
| Other Description |
3-oxo-5-alpha-steroid 4-dehydrogenase 2|5 alpha-SR2|S5AR 2|SR type 2|steroid 5-alpha-reductase 2|type II 5-alpha reductase
|
| Swissprots |
P31213 Q2M1R4 Q9BYE6 B2RE87
|
| Accessions |
AAW56942 BAB40419 EAX00478 P31213 AK307235 AK316597 BAG38184 BC112252 AAI12253 BC113641 AAI13642 EF560740 ABQ59050 EU832809 ACE87820 GQ129244 ACT64378 HQ258121 ADR82875 M74047 AAA60586 XM_011533068 XP_011531370 XM_011533069 XP_011531371 XM_011533070 XP_011531372 XM_011533071 XP_011531373 XM_011533072 XP_011531374 NM_000348 NP_000339
|
| Function |
Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
|
| Subcellular Location |
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in high levels in the prostate and many other androgen-sensitive tissues.
|
| Top Pathways |
Steroid hormone biosynthesis, Prostate cancer
|