| Gene Symbol |
CLIC2
|
| Entrez Gene |
1193
|
| Alt Symbol |
CLIC2b, MRXS32, XAP121
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chloride intracellular channel 2
|
| Other Description |
chloride intracellular channel protein 2
|
| Swissprots |
Q8TCE3 O15174 O15247 Q5JT80 A8K9S0
|
| Accessions |
CAA03948 CAI41464 CAO77905 EAW72624 EAW72625 O15247 AK292785 BAF85474 AM393055 CAL37933 AW961768 AY191592 AAO38670 BC005367 BC022305 AAH22305 BQ004708 BX482109 CD691162 DA901964 DQ892014 ABM82940 DQ895204 ABM86130 Y12696 CAA73228 NM_001289 NP_001280
|
| Function |
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. {ECO:0000269|PubMed:15147738, ECO:0000269|PubMed:15916532, ECO:0000269|PubMed:17945253}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15916532}. Membrane {ECO:0000305|PubMed:15916532}; Single-pass membrane protein {ECO:0000305|PubMed:15916532}. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
|
| Tissue Specificity |
Expressed in adult and fetal brain, heart, skeletal muscle, liver, lung, and spleen. Detected in adult stomach and testis. Expressed in fetal thymus and kidney. {ECO:0000269|PubMed:15147738, ECO:0000269|PubMed:22814392}.
|