| Gene Symbol |
TNR
|
| Entrez Gene |
7143
|
| Alt Symbol |
TN-R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tenascin R
|
| Other Description |
janusin|restrictin|tenascin-R
|
| Swissprots |
Q15568 C9J563 Q5R3G0 Q92752
|
| Accessions |
EAW90994 EAW90995 Q92752 AK295823 BAG58640 AV650210 BC129830 AAI29831 DA804585 DB068074 X98085 CAA66709 Y13359 Z67996 CAA91947 XM_011509947 XP_011508249 XM_011509948 XP_011508250 XM_011509949 XP_011508251 NM_003285 NP_003276
|
| Function |
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adh
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix.
|
| Tissue Specificity |
Brain specific. {ECO:0000269|PubMed:8626505}.
|
| Top Pathways |
Focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway, MicroRNAs in cancer
|