TNR

Gene Symbol	TNR
Entrez Gene	7143
Alt Symbol	TN-R
Species	Human
Gene Type	protein-coding
Description	tenascin R
Other Description	janusin|restrictin|tenascin-R
Swissprots	Q15568 C9J563 Q5R3G0 Q92752
Accessions	EAW90994 EAW90995 Q92752 AK295823 BAG58640 AV650210 BC129830 AAI29831 DA804585 DB068074 X98085 CAA66709 Y13359 Z67996 CAA91947 XM_011509947 XP_011508249 XM_011509948 XP_011508250 XM_011509949 XP_011508251 NM_003285 NP_003276
Function	Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adh
Subcellular Location	Secreted, extracellular space, extracellular matrix.
Tissue Specificity	Brain specific. {ECO:0000269|PubMed:8626505}.
Top Pathways	Focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TNR protein fragment - ab159731 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human Tenascin R Protein - H00007143-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Tenascin R, CF - 3865-TR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Glu34-Phe1358, with a C-terminal 6-His tag

TNR fusion protein - Ag18504 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TNR fusion protein - ag18194 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human TNR, His-tagged - TNR-3339H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Tenascin-R(TNR) ,partial - CSB-YP852903HU CSB-EP852903HU CSB-BP852903HU CSB-MP852903HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Tenascin R Protein, CF - 3865-TR from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Glu34-Phe1358, with a C-terminal 6-His tag Species Human

Tenascin-R / TNR - TP320277 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Tenascin-R (TNR), partial, Recombinant Protein - MBS1475058 from MyBioSource Category Protein Prices $995.00, $995.00, $1,225.00, $1,225.00, $1,475.00, $1,475.00, $1,935.00, $1,935.00, $1,955.00, $2,905.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Tenascin R (TNR) - RPB328Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Tenascin R Recombinant Protein Antigen - NBP1-86350PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Tenascin R Recombinant Protein Antigen - NBP1-86399PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Tenascin R Recombinant Protein Antigen - NBP1-86398PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TNR Peptide, Human - M34GP16408H from Creative Peptides Category Peptide Source Synthetic. Species Human

Tenascin R, Recombinant Protein - MBS2034116 from MyBioSource Category Protein Prices $185.00, $385.00, $595.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic Expression Species Rat

Recombinant Human Tenascin R Protein, CF - 3865-TR from Novus Biologicals Category Protein Prices $329.00 Sizes 50 µg Species Human

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