| Gene Symbol |
RNF6
|
| Entrez Gene |
6049
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein (C3H2C3 type) 6
|
| Other Description |
E3 ubiquitin-protein ligase RNF6|RING-H2 protein RNF-6
|
| Swissprots |
Q9BZP5 Q5W0H0 B4DDP0 Q9UF41 Q9Y252
|
| Accessions |
EAX08380 EAX08381 EAX08382 EAX08383 Q9Y252 AF293342 AAK00848 AJ010346 CAB40413 AJ010347 CAB40414 AK293272 BAG56801 AK312435 BAG35344 AL133621 CAB63747 AY009109 AAG49400 BC034688 AAH34688 BI461269 BP310130 BU633523 CR749238 CAH18094 DB062601 DC310579 DQ891481 ABM82407 DQ896825 ABM87824 XM_005266485 XP_005266542 XM_005266486 XP_005266543 XM_006719854 XP_006719917 XM_011535177 XP_011533479 XM_011535178 XP_011533480 NM_005977 NP_005968 NM_183043 NP_898864 NM_183044 NP_898865 NM_183045
|
| Function |
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. {ECO:0000269|PubMed:19345326}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19345326}. Cytoplasm {ECO:0000269|PubMed:19345326}. Cell projection, axon {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000250}.
|
| Tissue Specificity |
Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues. {ECO:0000269|PubMed:18368307, ECO:0000269|PubMed:19345326}.
|