RNF6

Gene Symbol	RNF6
Entrez Gene	6049
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	ring finger protein (C3H2C3 type) 6
Other Description	E3 ubiquitin-protein ligase RNF6|RING-H2 protein RNF-6
Swissprots	Q9BZP5 Q5W0H0 B4DDP0 Q9UF41 Q9Y252
Accessions	EAX08380 EAX08381 EAX08382 EAX08383 Q9Y252 AF293342 AAK00848 AJ010346 CAB40413 AJ010347 CAB40414 AK293272 BAG56801 AK312435 BAG35344 AL133621 CAB63747 AY009109 AAG49400 BC034688 AAH34688 BI461269 BP310130 BU633523 CR749238 CAH18094 DB062601 DC310579 DQ891481 ABM82407 DQ896825 ABM87824 XM_005266485 XP_005266542 XM_005266486 XP_005266543 XM_006719854 XP_006719917 XM_011535177 XP_011533479 XM_011535178 XP_011533480 NM_005977 NP_005968 NM_183043 NP_898864 NM_183044 NP_898865 NM_183045
Function	E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. {ECO:0000269|PubMed:19345326}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:19345326}. Cytoplasm {ECO:0000269|PubMed:19345326}. Cell projection, axon {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000250}.
Tissue Specificity	Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues. {ECO:0000269|PubMed:18368307, ECO:0000269|PubMed:19345326}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF6 peptide - ab23003 from Abcam Category Peptide Species Human

Human RNF6 protein fragment - ab159363 from Abcam Category Protein Source Wheat germ Species Human

RNF6 peptide - ab195206 from Abcam Category Peptide

RNF6 Antibody Blocking Peptide - LS-E6425 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF6 Antibody Blocking Peptide - LS-E15850 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF6 Antibody Blocking Peptide - LS-E15849 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNF6 Protein - H00006049-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF6-Antibody-C-term-Blocking-Peptide - BP19165b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF6 blocking peptide - GTX89833-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

RNF6 Blocking Peptide - 33R-5861 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF6 Blocking Peptide - 33R-5331 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF6 Blocking Peptide - 33R-9514 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF6 - H00006049-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF6 - H00006049-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF6 fusion protein - Ag14899 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RNF6 fusion protein - Ag14209 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human RNF6, His-tagged - RNF6-2348H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase RNF6(RNF6) - CSB-YP897080HU CSB-EP897080HU CSB-BP897080HU CSB-MP897080HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF6 Protein - NBP2-38445PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

RNF6 Recombinant Protein Antigen - NBP1-84107PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNF6 Peptide, Human - M34GP13443H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase RNF6 (RNF6), Recombinant Protein - MBS1370349 from MyBioSource Category Protein Prices $1,490.00, $1,490.00, $1,715.00, $1,715.00, $2,540.00, $2,540.00, $2,985.00, $2,985.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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