RNF6

Gene Symbol RNF6
Entrez Gene 6049
Alt Symbol -
Species Human
Gene Type protein-coding
Description ring finger protein (C3H2C3 type) 6
Other Description E3 ubiquitin-protein ligase RNF6|RING-H2 protein RNF-6
Swissprots Q9BZP5 Q5W0H0 B4DDP0 Q9UF41 Q9Y252
Accessions EAX08380 EAX08381 EAX08382 EAX08383 Q9Y252 AF293342 AAK00848 AJ010346 CAB40413 AJ010347 CAB40414 AK293272 BAG56801 AK312435 BAG35344 AL133621 CAB63747 AY009109 AAG49400 BC034688 AAH34688 BI461269 BP310130 BU633523 CR749238 CAH18094 DB062601 DC310579 DQ891481 ABM82407 DQ896825 ABM87824 XM_005266485 XP_005266542 XM_005266486 XP_005266543 XM_006719854 XP_006719917 XM_011535177 XP_011533479 XM_011535178 XP_011533480 NM_005977 NP_005968 NM_183043 NP_898864 NM_183044 NP_898865 NM_183045
Function E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. {ECO:0000269|PubMed:19345326}.
Subcellular Location Nucleus {ECO:0000269|PubMed:19345326}. Cytoplasm {ECO:0000269|PubMed:19345326}. Cell projection, axon {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000250}.
Tissue Specificity Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues. {ECO:0000269|PubMed:18368307, ECO:0000269|PubMed:19345326}.

RNF6 CRISPR/Cas9 KO Plasmid (h) - sc-406914 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF6 HDR Plasmid (h) - sc-406914-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF6 Double Nickase Plasmid (h) - sc-406914-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF6 Double Nickase Plasmid (h2) - sc-406914-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF6 CRISPR Activation Plasmid (h) - sc-406914-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF6 CRISPR Activation Plasmid (h2) - sc-406914-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF6 Lentiviral Activation Particles (h) - sc-406914-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF6 Lentiviral Activation Particles (h2) - sc-406914-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF6 siRNA (h) - sc-106519 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF6 shRNA Plasmid (h) - sc-106519-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF6 shRNA (h) Lentiviral Particles - sc-106519-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF6 RNAi - H00006049-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RNF6 RNAi - H00006049-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RNF6 RNAi - H00006049-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU125091 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18442 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18442 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08188 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08188

RNF6 siRNA (Human) - CRH4096 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF6 RNAi - H00006049-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RNF6 - MBS8210428 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNF6 (NM_005977.3) - SHH397408 from Creative biogene

Category siRNA
Species Reactivities Human

RNF6 shRNA Plasmid (Human) - CHH4096 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNF6 miRNA 3'UTR clone - MiUTR1H-08908 from Creative biogene

Species Reactivities Human

RNF6 miRNA 3'UTR clone - MiUTR3H-06670 from Creative biogene

Species Reactivities Human
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