| Gene Symbol |
MAGEA6
|
| Entrez Gene |
4105
|
| Alt Symbol |
CT1.6, MAGE-3b, MAGE3B, MAGE6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
melanoma antigen family A6
|
| Other Description |
MAGE-6 antigen|MAGE3B antigen|cancer/testis antigen 1.6|cancer/testis antigen family 1, member 6|melanoma antigen family A, 6|melanoma-associated antigen 6
|
| Swissprots |
P43360 A8IF93 Q6NW44
|
| Accessions |
AAA68875 P43360 AK289437 BAF82126 BC041599 AAH41599 BC067731 AAH67731 BM843807 BX640600 CAE45706 D32076 BAA06842 EU161101 ABW06860 U10339 AAA19006 XM_011531162 XP_011529464 NM_005363 NP_005354 NM_175868 NP_787064
|
| Function |
Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. {ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041}.
|
| Tissue Specificity |
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
|