Gene Symbol | MAGEA6 |
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Entrez Gene | 4105 |
Alt Symbol | CT1.6, MAGE-3b, MAGE3B, MAGE6 |
Species | Human |
Gene Type | protein-coding |
Description | melanoma antigen family A6 |
Other Description | MAGE-6 antigen|MAGE3B antigen|cancer/testis antigen 1.6|cancer/testis antigen family 1, member 6|melanoma antigen family A, 6|melanoma-associated antigen 6 |
Swissprots | P43360 A8IF93 Q6NW44 |
Accessions | AAA68875 P43360 AK289437 BAF82126 BC041599 AAH41599 BC067731 AAH67731 BM843807 BX640600 CAE45706 D32076 BAA06842 EU161101 ABW06860 U10339 AAA19006 XM_011531162 XP_011529464 NM_005363 NP_005354 NM_175868 NP_787064 |
Function | Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. {ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041}. |
Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. |
MAGE-A6 CRISPR/Cas9 KO Plasmid (h) - sc-402768 from Santa Cruz Biotechnology
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MAGE-A6 HDR Plasmid (h) - sc-402768-HDR from Santa Cruz Biotechnology
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MAGE-A6 Double Nickase Plasmid (h) - sc-402768-NIC from Santa Cruz Biotechnology
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MAGE-A6 Double Nickase Plasmid (h2) - sc-402768-NIC-2 from Santa Cruz Biotechnology
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MAGE-A6 CRISPR Activation Plasmid (h) - sc-402768-ACT from Santa Cruz Biotechnology
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MAGE-A6 CRISPR Activation Plasmid (h2) - sc-402768-ACT-2 from Santa Cruz Biotechnology
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MAGE-A6 Lentiviral Activation Particles (h) - sc-402768-LAC from Santa Cruz Biotechnology
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MAGE-A6 Lentiviral Activation Particles (h2) - sc-402768-LAC-2 from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU110611 from Sigma-Aldrich
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MISSION® esiRNA - EHU109291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12917 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12917 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05197 from Sigma-Aldrich
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MAGEA6 siRNA (Human) - CRH2785 from Cohesion Biosciences
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shRNA set against Human MAGEA6 (NM_175868.1) - SHH336775 from Creative biogene
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shRNA set against Human MAGEA6(NM_005363.2) - SHH170813 from Creative biogene
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Human MAGEA6 siRNA - orb263287 from Biorbyt
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MAGEA6 shRNA Plasmid (Human) - CHH2785 from Cohesion Biosciences
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MAGEA6 miRNA 3'UTR clone - MiUTR1H-06009 from Creative biogene
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