| Gene Symbol |
CDC26
|
| Entrez Gene |
246184
|
| Alt Symbol |
ANAPC12, APC12, C9orf17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cell division cycle 26
|
| Other Description |
CDC26 subunit of anaphase promoting complex|anaphase-promoting complex subunit 12|anaphase-promoting complex subunit CDC26|cell division cycle 26 homolog|cell division cycle protein 26 homolog
|
| Swissprots |
Q8NHZ8
|
| Accessions |
EAW87360 EAW87361 Q8NHZ8 AF503918 AAM34207 BC042534 AAH42534 BC066300 AAH66300 BF244254 BQ446788 CA446805 CD685602 HQ448488 ADQ32968 NM_139286 NP_644815
|
| Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269|PubMed:18485873}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection
|
