Gene Symbol | CDC26 |
---|---|
Entrez Gene | 246184 |
Alt Symbol | ANAPC12, APC12, C9orf17 |
Species | Human |
Gene Type | protein-coding |
Description | cell division cycle 26 |
Other Description | CDC26 subunit of anaphase promoting complex|anaphase-promoting complex subunit 12|anaphase-promoting complex subunit CDC26|cell division cycle 26 homolog|cell division cycle protein 26 homolog |
Swissprots | Q8NHZ8 |
Accessions | EAW87360 EAW87361 Q8NHZ8 AF503918 AAM34207 BC042534 AAH42534 BC066300 AAH66300 BF244254 BQ446788 CA446805 CD685602 HQ448488 ADQ32968 NM_139286 NP_644815 |
Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269|PubMed:18485873}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Top Pathways | Cell cycle, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection |